| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ILK | ITGA5 | ENSPPYP00000023691 | ENSPPYP00000005252 | Integrin-linked protein kinase; Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B. | ITGA5 isoform 1; Belongs to the integrin alpha chain family. | 0.933 |
| ILK | ITGB1 | ENSPPYP00000023691 | ENSPPYP00000002560 | Integrin-linked protein kinase; Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B. | Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] | 0.998 |
| ITGA1 | ITGA3 | ENSPPYP00000017264 | ENSPPYP00000010024 | Integrin subunit alpha 1; Belongs to the integrin alpha chain family. | Integrin subunit alpha 3; Belongs to the integrin alpha chain family. | 0.742 |
| ITGA1 | ITGA4 | ENSPPYP00000017264 | ENSPPYP00000014509 | Integrin subunit alpha 1; Belongs to the integrin alpha chain family. | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. | 0.704 |
| ITGA1 | ITGA5 | ENSPPYP00000017264 | ENSPPYP00000005252 | Integrin subunit alpha 1; Belongs to the integrin alpha chain family. | ITGA5 isoform 1; Belongs to the integrin alpha chain family. | 0.701 |
| ITGA1 | ITGA6 | ENSPPYP00000017264 | ENSPPYP00000014440 | Integrin subunit alpha 1; Belongs to the integrin alpha chain family. | ITGA6 isoform 6; Belongs to the integrin alpha chain family. | 0.713 |
| ITGA1 | ITGA7 | ENSPPYP00000017264 | ENSPPYP00000005272 | Integrin subunit alpha 1; Belongs to the integrin alpha chain family. | ITGA7 isoform 14; Belongs to the integrin alpha chain family. | 0.711 |
| ITGA1 | ITGA8 | ENSPPYP00000017264 | ENSPPYP00000002453 | Integrin subunit alpha 1; Belongs to the integrin alpha chain family. | ITGA8 isoform 1; Belongs to the integrin alpha chain family. | 0.704 |
| ITGA1 | ITGA9 | ENSPPYP00000017264 | ENSPPYP00000015679 | Integrin subunit alpha 1; Belongs to the integrin alpha chain family. | Integrin subunit alpha 9; Belongs to the integrin alpha chain family. | 0.694 |
| ITGA1 | ITGAV | ENSPPYP00000017264 | ENSPPYP00000014531 | Integrin subunit alpha 1; Belongs to the integrin alpha chain family. | ITGAV isoform 2; Belongs to the integrin alpha chain family. | 0.701 |
| ITGA1 | ITGB1 | ENSPPYP00000017264 | ENSPPYP00000002560 | Integrin subunit alpha 1; Belongs to the integrin alpha chain family. | Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] | 0.998 |
| ITGA3 | ITGA1 | ENSPPYP00000010024 | ENSPPYP00000017264 | Integrin subunit alpha 3; Belongs to the integrin alpha chain family. | Integrin subunit alpha 1; Belongs to the integrin alpha chain family. | 0.742 |
| ITGA3 | ITGA4 | ENSPPYP00000010024 | ENSPPYP00000014509 | Integrin subunit alpha 3; Belongs to the integrin alpha chain family. | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. | 0.793 |
| ITGA3 | ITGA5 | ENSPPYP00000010024 | ENSPPYP00000005252 | Integrin subunit alpha 3; Belongs to the integrin alpha chain family. | ITGA5 isoform 1; Belongs to the integrin alpha chain family. | 0.871 |
| ITGA3 | ITGA6 | ENSPPYP00000010024 | ENSPPYP00000014440 | Integrin subunit alpha 3; Belongs to the integrin alpha chain family. | ITGA6 isoform 6; Belongs to the integrin alpha chain family. | 0.797 |
| ITGA3 | ITGA7 | ENSPPYP00000010024 | ENSPPYP00000005272 | Integrin subunit alpha 3; Belongs to the integrin alpha chain family. | ITGA7 isoform 14; Belongs to the integrin alpha chain family. | 0.782 |
| ITGA3 | ITGA8 | ENSPPYP00000010024 | ENSPPYP00000002453 | Integrin subunit alpha 3; Belongs to the integrin alpha chain family. | ITGA8 isoform 1; Belongs to the integrin alpha chain family. | 0.752 |
| ITGA3 | ITGA9 | ENSPPYP00000010024 | ENSPPYP00000015679 | Integrin subunit alpha 3; Belongs to the integrin alpha chain family. | Integrin subunit alpha 9; Belongs to the integrin alpha chain family. | 0.727 |
| ITGA3 | ITGAV | ENSPPYP00000010024 | ENSPPYP00000014531 | Integrin subunit alpha 3; Belongs to the integrin alpha chain family. | ITGAV isoform 2; Belongs to the integrin alpha chain family. | 0.845 |
| ITGA3 | ITGB1 | ENSPPYP00000010024 | ENSPPYP00000002560 | Integrin subunit alpha 3; Belongs to the integrin alpha chain family. | Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] | 0.998 |
