| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACER2 | ASAH2B | ENSPPYP00000021499 | ENSPPYP00000003285 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | N-acylsphingosine amidohydrolase 2B. | 0.962 |
| ACER2 | CERK | ENSPPYP00000021499 | ENSPPYP00000013338 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Ceramide kinase. | 0.960 |
| ACER2 | DEGS1 | ENSPPYP00000021499 | ENSPPYP00000011912 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Sphingolipid delta(4)-desaturase DES1; Has sphingolipid-delta-4-desaturase activity. Converts D- erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine) (By similarity); Belongs to the fatty acid desaturase type 1 family. DEGS subfamily. | 0.929 |
| ACER2 | DEGS2 | ENSPPYP00000021499 | ENSPPYP00000006979 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | DEGS2 isoform 1. | 0.925 |
| ACER2 | GBA2 | ENSPPYP00000021499 | ENSPPYP00000021384 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. | 0.920 |
| ACER2 | SAMD8 | ENSPPYP00000021499 | ENSPPYP00000002689 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | SAMD8 isoform 3. | 0.926 |
| ACER2 | SMPD1 | ENSPPYP00000021499 | ENSPPYP00000004065 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. | 0.938 |
| ACER2 | SMPD2 | ENSPPYP00000021499 | ENSPPYP00000018928 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | SMPD2 isoform 1. | 0.944 |
| ACER2 | SMPD4 | ENSPPYP00000021499 | ENSPPYP00000014958 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | SMPD4 isoform 1. | 0.920 |
| ACER2 | UGCG | ENSPPYP00000021499 | ENSPPYP00000021849 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | UGCG isoform 1. | 0.929 |
| ASAH2B | ACER2 | ENSPPYP00000003285 | ENSPPYP00000021499 | N-acylsphingosine amidohydrolase 2B. | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | 0.962 |
| ASAH2B | CERK | ENSPPYP00000003285 | ENSPPYP00000013338 | N-acylsphingosine amidohydrolase 2B. | Ceramide kinase. | 0.960 |
| ASAH2B | DEGS1 | ENSPPYP00000003285 | ENSPPYP00000011912 | N-acylsphingosine amidohydrolase 2B. | Sphingolipid delta(4)-desaturase DES1; Has sphingolipid-delta-4-desaturase activity. Converts D- erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine) (By similarity); Belongs to the fatty acid desaturase type 1 family. DEGS subfamily. | 0.920 |
| ASAH2B | DEGS2 | ENSPPYP00000003285 | ENSPPYP00000006979 | N-acylsphingosine amidohydrolase 2B. | DEGS2 isoform 1. | 0.920 |
| ASAH2B | GBA2 | ENSPPYP00000003285 | ENSPPYP00000021384 | N-acylsphingosine amidohydrolase 2B. | Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. | 0.944 |
| ASAH2B | SAMD8 | ENSPPYP00000003285 | ENSPPYP00000002689 | N-acylsphingosine amidohydrolase 2B. | SAMD8 isoform 3. | 0.929 |
| ASAH2B | SMPD1 | ENSPPYP00000003285 | ENSPPYP00000004065 | N-acylsphingosine amidohydrolase 2B. | Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. | 0.936 |
| ASAH2B | SMPD2 | ENSPPYP00000003285 | ENSPPYP00000018928 | N-acylsphingosine amidohydrolase 2B. | SMPD2 isoform 1. | 0.946 |
| ASAH2B | SMPD4 | ENSPPYP00000003285 | ENSPPYP00000014958 | N-acylsphingosine amidohydrolase 2B. | SMPD4 isoform 1. | 0.926 |
| ASAH2B | UGCG | ENSPPYP00000003285 | ENSPPYP00000021849 | N-acylsphingosine amidohydrolase 2B. | UGCG isoform 1. | 0.949 |
