| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AMPD1 | DUPD1 | ENSPPYP00000001164 | ENSPPYP00000002691 | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.505 |
| DUPD1 | AMPD1 | ENSPPYP00000002691 | ENSPPYP00000001164 | Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | 0.505 |
| DUPD1 | DYSF | ENSPPYP00000002691 | ENSPPYP00000013726 | Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | DYSF isoform 11. | 0.591 |
| DUPD1 | FKBP1A | ENSPPYP00000002691 | ENSPPYP00000012122 | Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Peptidylprolyl isomerase. | 0.715 |
| DUPD1 | ITGB7 | ENSPPYP00000002691 | ENSPPYP00000005214 | Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Integrin beta; Belongs to the integrin beta chain family. | 0.416 |
| DUPD1 | MOB1A | ENSPPYP00000002691 | ENSPPYP00000013698 | Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | MOB kinase activator 1A; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellu [...] | 0.407 |
| DUPD1 | MTHFSD | ENSPPYP00000002691 | ENSPPYP00000008601 | Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | MTHFSD isoform 6. | 0.445 |
| DUPD1 | PSMD1 | ENSPPYP00000002691 | ENSPPYP00000014825 | Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. | 0.424 |
| DUPD1 | RPL5 | ENSPPYP00000002691 | ENSPPYP00000001336 | Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Ribosomal protein L5. | 0.585 |
| DUPD1 | UTP15 | ENSPPYP00000002691 | ENSPPYP00000017381 | Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | U3 small nucleolar RNA-associated protein 15 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA. | 0.418 |
| DUPD1 | VRK3 | ENSPPYP00000002691 | ENSPPYP00000011500 | Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | VRK3 isoform 3. | 0.488 |
| DYSF | DUPD1 | ENSPPYP00000013726 | ENSPPYP00000002691 | DYSF isoform 11. | Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.591 |
| DYSF | FKBP1A | ENSPPYP00000013726 | ENSPPYP00000012122 | DYSF isoform 11. | Peptidylprolyl isomerase. | 0.493 |
| DYSF | RPL5 | ENSPPYP00000013726 | ENSPPYP00000001336 | DYSF isoform 11. | Ribosomal protein L5. | 0.424 |
| FKBP1A | DUPD1 | ENSPPYP00000012122 | ENSPPYP00000002691 | Peptidylprolyl isomerase. | Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.715 |
| FKBP1A | DYSF | ENSPPYP00000012122 | ENSPPYP00000013726 | Peptidylprolyl isomerase. | DYSF isoform 11. | 0.493 |
| FKBP1A | RPL5 | ENSPPYP00000012122 | ENSPPYP00000001336 | Peptidylprolyl isomerase. | Ribosomal protein L5. | 0.587 |
| ITGB7 | DUPD1 | ENSPPYP00000005214 | ENSPPYP00000002691 | Integrin beta; Belongs to the integrin beta chain family. | Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.416 |
| MOB1A | DUPD1 | ENSPPYP00000013698 | ENSPPYP00000002691 | MOB kinase activator 1A; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellu [...] | Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.407 |
| MTHFSD | DUPD1 | ENSPPYP00000008601 | ENSPPYP00000002691 | MTHFSD isoform 6. | Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.445 |