PSAP protein (Pongo abelii) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

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experimentally determined

co-expression

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gene neighborhood

gene co-occurrence

gene fusions

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[Homology]

Score

PSAP

PSAP isoform 2. (526 aa)

Predicted Functional Partners:

GLA

0.955

GBA

0.936

PSAPL1

0.901

ARSA

0.877

GPR37L1

0.872

GALC

0.854

CR201_G0030452

0.776

GPR37

0.776

NAGA

0.740

HEXB

0.737

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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structured XML interaction data, according to the 'PSI-MI' data standard

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... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARSA	GALC	ENSPPYP00000013382	ENSPPYP00000006875	ARSA isoform 3.	GALC isoform 2.	0.961
ARSA	GBA	ENSPPYP00000013382	ENSPPYP00000000872	ARSA isoform 3.	Lysosomal acid glucosylceramidase; Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates to the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol. [...]	0.430
ARSA	GLA	ENSPPYP00000013382	ENSPPYP00000023601	ARSA isoform 3.	Alpha-galactosidase.	0.950
ARSA	HEXB	ENSPPYP00000013382	ENSPPYP00000024213	ARSA isoform 3.	Beta-hexosaminidase.	0.922
ARSA	PSAP	ENSPPYP00000013382	ENSPPYP00000002736	ARSA isoform 3.	PSAP isoform 2.	0.877
ARSA	PSAPL1	ENSPPYP00000013382	ENSPPYP00000016281	ARSA isoform 3.	PSAPL1 isoform 1.	0.783
CR201_G0030452	PSAP	ENSPPYP00000020149	ENSPPYP00000002736	GPR37 isoform 1.	PSAP isoform 2.	0.776
CR201_G0030452	PSAPL1	ENSPPYP00000020149	ENSPPYP00000016281	GPR37 isoform 1.	PSAPL1 isoform 1.	0.776
GALC	ARSA	ENSPPYP00000006875	ENSPPYP00000013382	GALC isoform 2.	ARSA isoform 3.	0.961
GALC	GBA	ENSPPYP00000006875	ENSPPYP00000000872	GALC isoform 2.	Lysosomal acid glucosylceramidase; Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates to the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol. [...]	0.950
GALC	GLA	ENSPPYP00000006875	ENSPPYP00000023601	GALC isoform 2.	Alpha-galactosidase.	0.948
GALC	PSAP	ENSPPYP00000006875	ENSPPYP00000002736	GALC isoform 2.	PSAP isoform 2.	0.854
GALC	PSAPL1	ENSPPYP00000006875	ENSPPYP00000016281	GALC isoform 2.	PSAPL1 isoform 1.	0.765
GBA	ARSA	ENSPPYP00000000872	ENSPPYP00000013382	Lysosomal acid glucosylceramidase; Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates to the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol. [...]	ARSA isoform 3.	0.430
GBA	GALC	ENSPPYP00000000872	ENSPPYP00000006875	Lysosomal acid glucosylceramidase; Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates to the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol. [...]	GALC isoform 2.	0.950
GBA	GLA	ENSPPYP00000000872	ENSPPYP00000023601	Lysosomal acid glucosylceramidase; Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates to the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol. [...]	Alpha-galactosidase.	0.540
GBA	PSAP	ENSPPYP00000000872	ENSPPYP00000002736	Lysosomal acid glucosylceramidase; Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates to the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol. [...]	PSAP isoform 2.	0.936
GBA	PSAPL1	ENSPPYP00000000872	ENSPPYP00000016281	Lysosomal acid glucosylceramidase; Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates to the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol. [...]	PSAPL1 isoform 1.	0.888
GLA	ARSA	ENSPPYP00000023601	ENSPPYP00000013382	Alpha-galactosidase.	ARSA isoform 3.	0.950
GLA	GALC	ENSPPYP00000023601	ENSPPYP00000006875	Alpha-galactosidase.	GALC isoform 2.	0.948