SGPL1 protein (Pongo abelii) - STRING interaction network

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SGPL1

Sphingosine-1-phosphate lyase 1; Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis (By similarity). Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP (By similarity). Seems to play a role in establish [...] (568 aa)

Predicted Functional Partners:

SPHK1

0.978

SPHK2

0.978

SGPP1

0.974

SGPP2

0.972

PLPP3

0.933

PLPP2

0.931

ADAMTS14

0.663

RTN4

0.635

ABAT

0.612

RIMS2

0.576

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABAT	SGPL1	ENSPPYP00000008008	ENSPPYP00000002746	ABAT isoform 1; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Sphingosine-1-phosphate lyase 1; Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis (By similarity). Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP (By similarity). Seems to play a role in establish [...]	0.612
ADAMTS14	SGPL1	ENSPPYP00000002748	ENSPPYP00000002746	ADAMTS14 isoform 1.	Sphingosine-1-phosphate lyase 1; Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis (By similarity). Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP (By similarity). Seems to play a role in establish [...]	0.663
PLPP2	PLPP3	ENSPPYP00000010401	ENSPPYP00000001520	PLPP2 isoform 1.	T0071805 isoform 3.	0.917
PLPP2	SGPL1	ENSPPYP00000010401	ENSPPYP00000002746	PLPP2 isoform 1.	Sphingosine-1-phosphate lyase 1; Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis (By similarity). Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP (By similarity). Seems to play a role in establish [...]	0.931
PLPP2	SGPP1	ENSPPYP00000010401	ENSPPYP00000006699	PLPP2 isoform 1.	Sphingosine-1-phosphate phosphatase 1.	0.924
PLPP2	SGPP2	ENSPPYP00000010401	ENSPPYP00000014774	PLPP2 isoform 1.	SGPP2 isoform 1.	0.943
PLPP2	SPHK1	ENSPPYP00000010401	ENSPPYP00000009724	PLPP2 isoform 1.	SPHK1 isoform 7.	0.919
PLPP2	SPHK2	ENSPPYP00000010401	ENSPPYP00000011413	PLPP2 isoform 1.	SPHK2 isoform 2.	0.920
PLPP3	PLPP2	ENSPPYP00000001520	ENSPPYP00000010401	T0071805 isoform 3.	PLPP2 isoform 1.	0.917
PLPP3	SGPL1	ENSPPYP00000001520	ENSPPYP00000002746	T0071805 isoform 3.	Sphingosine-1-phosphate lyase 1; Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis (By similarity). Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP (By similarity). Seems to play a role in establish [...]	0.933
PLPP3	SGPP1	ENSPPYP00000001520	ENSPPYP00000006699	T0071805 isoform 3.	Sphingosine-1-phosphate phosphatase 1.	0.927
PLPP3	SGPP2	ENSPPYP00000001520	ENSPPYP00000014774	T0071805 isoform 3.	SGPP2 isoform 1.	0.927
PLPP3	SPHK1	ENSPPYP00000001520	ENSPPYP00000009724	T0071805 isoform 3.	SPHK1 isoform 7.	0.935
PLPP3	SPHK2	ENSPPYP00000001520	ENSPPYP00000011413	T0071805 isoform 3.	SPHK2 isoform 2.	0.935
RIMS2	SGPL1	ENSPPYP00000021101	ENSPPYP00000002746	Regulating synaptic membrane exocytosis 2.	Sphingosine-1-phosphate lyase 1; Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis (By similarity). Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP (By similarity). Seems to play a role in establish [...]	0.576
RTN4	SGPL1	ENSPPYP00000013843	ENSPPYP00000002746	Reticulon.	Sphingosine-1-phosphate lyase 1; Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis (By similarity). Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP (By similarity). Seems to play a role in establish [...]	0.635
SGPL1	ABAT	ENSPPYP00000002746	ENSPPYP00000008008	Sphingosine-1-phosphate lyase 1; Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis (By similarity). Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP (By similarity). Seems to play a role in establish [...]	ABAT isoform 1; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.612
SGPL1	ADAMTS14	ENSPPYP00000002746	ENSPPYP00000002748	Sphingosine-1-phosphate lyase 1; Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis (By similarity). Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP (By similarity). Seems to play a role in establish [...]	ADAMTS14 isoform 1.	0.663
SGPL1	PLPP2	ENSPPYP00000002746	ENSPPYP00000010401	Sphingosine-1-phosphate lyase 1; Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis (By similarity). Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP (By similarity). Seems to play a role in establish [...]	PLPP2 isoform 1.	0.931
SGPL1	PLPP3	ENSPPYP00000002746	ENSPPYP00000001520	Sphingosine-1-phosphate lyase 1; Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis (By similarity). Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP (By similarity). Seems to play a role in establish [...]	T0071805 isoform 3.	0.933

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