| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCAR2 | SIRT1 | ENSPPYP00000020648 | ENSPPYP00000002788 | Cell cycle and apoptosis regulator protein 2; Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53- mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part [...] | SIRT1 isoform 1. | 0.998 |
| FOXO1 | FOXO3 | ENSPPYP00000006042 | ENSPPYP00000018917 | FOXO1 isoform 1. | FOXO3 isoform 1. | 0.972 |
| FOXO1 | PPARG | ENSPPYP00000006042 | ENSPPYP00000015259 | FOXO1 isoform 1. | Peroxisome proliferator-activated receptor gamma. | 0.603 |
| FOXO1 | PPARGC1A | ENSPPYP00000006042 | ENSPPYP00000016357 | FOXO1 isoform 1. | PPARG coactivator 1 alpha. | 0.993 |
| FOXO1 | SIRT1 | ENSPPYP00000006042 | ENSPPYP00000002788 | FOXO1 isoform 1. | SIRT1 isoform 1. | 0.997 |
| FOXO1 | SIRT6 | ENSPPYP00000006042 | ENSPPYP00000010537 | FOXO1 isoform 1. | SIRT6 isoform 1. | 0.470 |
| FOXO1 | SIRT7 | ENSPPYP00000006042 | ENSPPYP00000009825 | FOXO1 isoform 1. | SIRT7 isoform 2. | 0.422 |
| FOXO1 | TP53 | ENSPPYP00000006042 | ENSPPYP00000008923 | FOXO1 isoform 1. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.847 |
| FOXO3 | FOXO1 | ENSPPYP00000018917 | ENSPPYP00000006042 | FOXO3 isoform 1. | FOXO1 isoform 1. | 0.972 |
| FOXO3 | PPARG | ENSPPYP00000018917 | ENSPPYP00000015259 | FOXO3 isoform 1. | Peroxisome proliferator-activated receptor gamma. | 0.554 |
| FOXO3 | PPARGC1A | ENSPPYP00000018917 | ENSPPYP00000016357 | FOXO3 isoform 1. | PPARG coactivator 1 alpha. | 0.794 |
| FOXO3 | SIRT1 | ENSPPYP00000018917 | ENSPPYP00000002788 | FOXO3 isoform 1. | SIRT1 isoform 1. | 0.995 |
| FOXO3 | SIRT6 | ENSPPYP00000018917 | ENSPPYP00000010537 | FOXO3 isoform 1. | SIRT6 isoform 1. | 0.527 |
| FOXO3 | SIRT7 | ENSPPYP00000018917 | ENSPPYP00000009825 | FOXO3 isoform 1. | SIRT7 isoform 2. | 0.415 |
| FOXO3 | TP53 | ENSPPYP00000018917 | ENSPPYP00000008923 | FOXO3 isoform 1. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.904 |
| NAMPT | PPARG | ENSPPYP00000020466 | ENSPPYP00000015259 | Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. | Peroxisome proliferator-activated receptor gamma. | 0.402 |
| NAMPT | SIRT1 | ENSPPYP00000020466 | ENSPPYP00000002788 | Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. | SIRT1 isoform 1. | 0.961 |
| NAMPT | SIRT6 | ENSPPYP00000020466 | ENSPPYP00000010537 | Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. | SIRT6 isoform 1. | 0.936 |
| NAMPT | SIRT7 | ENSPPYP00000020466 | ENSPPYP00000009825 | Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. | SIRT7 isoform 2. | 0.921 |
| PPARG | FOXO1 | ENSPPYP00000015259 | ENSPPYP00000006042 | Peroxisome proliferator-activated receptor gamma. | FOXO1 isoform 1. | 0.603 |
