| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CH25H | CR201_G0032337-2 | ENSPPYP00000002851 | ENSPPYP00000014972 | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. | CYP27A1 isoform 5. | 0.936 |
| CH25H | CYP46A1 | ENSPPYP00000002851 | ENSPPYP00000006975 | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. | CYP46A1 isoform 2; Belongs to the cytochrome P450 family. | 0.952 |
| CH25H | CYP51A1 | ENSPPYP00000002851 | ENSPPYP00000019976 | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | 0.962 |
| CH25H | CYP7A1 | ENSPPYP00000002851 | ENSPPYP00000020869 | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. | 0.968 |
| CH25H | CYP7B1 | ENSPPYP00000002851 | ENSPPYP00000020894 | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. | Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. | 0.979 |
| CH25H | DHCR24 | ENSPPYP00000002851 | ENSPPYP00000001525 | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. | DHCR24 isoform 1. | 0.912 |
| CH25H | DHCR7 | ENSPPYP00000002851 | ENSPPYP00000003422 | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. | DHCR7 isoform 1. | 0.946 |
| CH25H | HMGCS1 | ENSPPYP00000002851 | ENSPPYP00000017251 | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. | Hydroxymethylglutaryl-CoA synthase, cytoplasmic; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 0.880 |
| CH25H | SC5D | ENSPPYP00000002851 | ENSPPYP00000004558 | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. | Sterol-C5-desaturase; Belongs to the sterol desaturase family. | 0.905 |
| CH25H | SQLE | ENSPPYP00000002851 | ENSPPYP00000021174 | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. | SQLE isoform 1. | 0.949 |
| CR201_G0032337-2 | CH25H | ENSPPYP00000014972 | ENSPPYP00000002851 | CYP27A1 isoform 5. | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. | 0.936 |
| CR201_G0032337-2 | CYP46A1 | ENSPPYP00000014972 | ENSPPYP00000006975 | CYP27A1 isoform 5. | CYP46A1 isoform 2; Belongs to the cytochrome P450 family. | 0.927 |
| CR201_G0032337-2 | CYP7A1 | ENSPPYP00000014972 | ENSPPYP00000020869 | CYP27A1 isoform 5. | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. | 0.984 |
| CR201_G0032337-2 | CYP7B1 | ENSPPYP00000014972 | ENSPPYP00000020894 | CYP27A1 isoform 5. | Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. | 0.969 |
| CR201_G0032337-2 | DHCR24 | ENSPPYP00000014972 | ENSPPYP00000001525 | CYP27A1 isoform 5. | DHCR24 isoform 1. | 0.830 |
| CR201_G0032337-2 | DHCR7 | ENSPPYP00000014972 | ENSPPYP00000003422 | CYP27A1 isoform 5. | DHCR7 isoform 1. | 0.876 |
| CYP46A1 | CH25H | ENSPPYP00000006975 | ENSPPYP00000002851 | CYP46A1 isoform 2; Belongs to the cytochrome P450 family. | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. | 0.952 |
| CYP46A1 | CR201_G0032337-2 | ENSPPYP00000006975 | ENSPPYP00000014972 | CYP46A1 isoform 2; Belongs to the cytochrome P450 family. | CYP27A1 isoform 5. | 0.927 |
| CYP46A1 | CYP51A1 | ENSPPYP00000006975 | ENSPPYP00000019976 | CYP46A1 isoform 2; Belongs to the cytochrome P450 family. | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | 0.520 |
| CYP46A1 | CYP7A1 | ENSPPYP00000006975 | ENSPPYP00000020869 | CYP46A1 isoform 2; Belongs to the cytochrome P450 family. | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. | 0.962 |
