| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APPBP2 | PYROXD2 | ENSPPYP00000009567 | ENSPPYP00000002956 | Amyloid beta precursor protein binding protein 2. | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2; Probable oxidoreductase. | 0.586 |
| BCKDHA | PYROXD2 | ENSPPYP00000011210 | ENSPPYP00000002956 | 2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2; Probable oxidoreductase. | 0.600 |
| FDFT1 | NDUFAF6 | ENSPPYP00000020559 | ENSPPYP00000021041 | Squalene synthase; Critical branch point enzyme of isoprenoid biosynthesis that is thought to regulate the flux of isoprene intermediates through the sterol pathway; Belongs to the phytoene/squalene synthase family. | NDUFAF6 isoform 7. | 0.432 |
| FDFT1 | PYROXD2 | ENSPPYP00000020559 | ENSPPYP00000002956 | Squalene synthase; Critical branch point enzyme of isoprenoid biosynthesis that is thought to regulate the flux of isoprene intermediates through the sterol pathway; Belongs to the phytoene/squalene synthase family. | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2; Probable oxidoreductase. | 0.830 |
| FH | PYROXD2 | ENSPPYP00000000069 | ENSPPYP00000002956 | Fumarate hydratase. | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2; Probable oxidoreductase. | 0.576 |
| GALE | PYROXD2 | ENSPPYP00000002005 | ENSPPYP00000002956 | UDP-glucose 4-epimerase; Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversi [...] | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2; Probable oxidoreductase. | 0.600 |
| GPD2 | PYROXD2 | ENSPPYP00000014353 | ENSPPYP00000002956 | Glycerol-3-phosphate dehydrogenase; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2; Probable oxidoreductase. | 0.628 |
| GPD2 | SPATA20 | ENSPPYP00000014353 | ENSPPYP00000009301 | Glycerol-3-phosphate dehydrogenase; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. | Spermatogenesis-associated protein 20; May play a role in fertility regulation. | 0.709 |
| NDUFAF6 | FDFT1 | ENSPPYP00000021041 | ENSPPYP00000020559 | NDUFAF6 isoform 7. | Squalene synthase; Critical branch point enzyme of isoprenoid biosynthesis that is thought to regulate the flux of isoprene intermediates through the sterol pathway; Belongs to the phytoene/squalene synthase family. | 0.432 |
| NDUFAF6 | PYROXD2 | ENSPPYP00000021041 | ENSPPYP00000002956 | NDUFAF6 isoform 7. | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2; Probable oxidoreductase. | 0.782 |
| PYROXD2 | APPBP2 | ENSPPYP00000002956 | ENSPPYP00000009567 | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2; Probable oxidoreductase. | Amyloid beta precursor protein binding protein 2. | 0.586 |
| PYROXD2 | BCKDHA | ENSPPYP00000002956 | ENSPPYP00000011210 | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2; Probable oxidoreductase. | 2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). | 0.600 |
| PYROXD2 | FDFT1 | ENSPPYP00000002956 | ENSPPYP00000020559 | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2; Probable oxidoreductase. | Squalene synthase; Critical branch point enzyme of isoprenoid biosynthesis that is thought to regulate the flux of isoprene intermediates through the sterol pathway; Belongs to the phytoene/squalene synthase family. | 0.830 |
| PYROXD2 | FH | ENSPPYP00000002956 | ENSPPYP00000000069 | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2; Probable oxidoreductase. | Fumarate hydratase. | 0.576 |
| PYROXD2 | GALE | ENSPPYP00000002956 | ENSPPYP00000002005 | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2; Probable oxidoreductase. | UDP-glucose 4-epimerase; Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversi [...] | 0.600 |
| PYROXD2 | GPD2 | ENSPPYP00000002956 | ENSPPYP00000014353 | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2; Probable oxidoreductase. | Glycerol-3-phosphate dehydrogenase; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. | 0.628 |
| PYROXD2 | NDUFAF6 | ENSPPYP00000002956 | ENSPPYP00000021041 | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2; Probable oxidoreductase. | NDUFAF6 isoform 7. | 0.782 |
| PYROXD2 | SPATA20 | ENSPPYP00000002956 | ENSPPYP00000009301 | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2; Probable oxidoreductase. | Spermatogenesis-associated protein 20; May play a role in fertility regulation. | 0.602 |
| PYROXD2 | TPD52L2 | ENSPPYP00000002956 | ENSPPYP00000012569 | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2; Probable oxidoreductase. | Tumor protein D54. | 0.635 |
| PYROXD2 | TYW3 | ENSPPYP00000002956 | ENSPPYP00000001435 | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2; Probable oxidoreductase. | tRNA wybutosine-synthesizing protein 3 homolog; Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity). | 0.545 |
