| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CUL3 | GLI1 | ENSPPYP00000014786 | ENSPPYP00000005342 | CUL3 isoform 1; Belongs to the cullin family. | GLI family zinc finger 1. | 0.956 |
| CUL3 | GLI2 | ENSPPYP00000014786 | ENSPPYP00000014260 | CUL3 isoform 1; Belongs to the cullin family. | GLI2 isoform 1. | 0.968 |
| CUL3 | GLI3 | ENSPPYP00000014786 | ENSPPYP00000019741 | CUL3 isoform 1; Belongs to the cullin family. | GLI3 isoform 3. | 0.961 |
| CUL3 | SPOP | ENSPPYP00000014786 | ENSPPYP00000010012 | CUL3 isoform 1; Belongs to the cullin family. | Speckle-type POZ protein; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of MACROH2A1 and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation. The cullin-RING- [...] | 0.998 |
| CUL3 | SPOPL | ENSPPYP00000014786 | ENSPPYP00000014314 | CUL3 isoform 1; Belongs to the cullin family. | Speckle type BTB/POZ protein like. | 0.992 |
| CUL3 | SUFU | ENSPPYP00000014786 | ENSPPYP00000003030 | CUL3 isoform 1; Belongs to the cullin family. | Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] | 0.953 |
| GLI1 | CUL3 | ENSPPYP00000005342 | ENSPPYP00000014786 | GLI family zinc finger 1. | CUL3 isoform 1; Belongs to the cullin family. | 0.956 |
| GLI1 | GLI2 | ENSPPYP00000005342 | ENSPPYP00000014260 | GLI family zinc finger 1. | GLI2 isoform 1. | 0.991 |
| GLI1 | GLI3 | ENSPPYP00000005342 | ENSPPYP00000019741 | GLI family zinc finger 1. | GLI3 isoform 3. | 0.987 |
| GLI1 | KIF7 | ENSPPYP00000005342 | ENSPPYP00000007677 | GLI family zinc finger 1. | KIF7 isoform 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.965 |
| GLI1 | SMO | ENSPPYP00000005342 | ENSPPYP00000020186 | GLI family zinc finger 1. | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.926 |
| GLI1 | SPOP | ENSPPYP00000005342 | ENSPPYP00000010012 | GLI family zinc finger 1. | Speckle-type POZ protein; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of MACROH2A1 and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation. The cullin-RING- [...] | 0.968 |
| GLI1 | SPOPL | ENSPPYP00000005342 | ENSPPYP00000014314 | GLI family zinc finger 1. | Speckle type BTB/POZ protein like. | 0.967 |
| GLI1 | STK36 | ENSPPYP00000005342 | ENSPPYP00000014729 | GLI family zinc finger 1. | Serine/threonine-protein kinase 36; Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur. Required for postnatal development, possibly by regulating the homeostasis of c [...] | 0.910 |
| GLI1 | SUFU | ENSPPYP00000005342 | ENSPPYP00000003030 | GLI family zinc finger 1. | Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] | 0.999 |
| GLI1 | ULK3 | ENSPPYP00000005342 | ENSPPYP00000007541 | GLI family zinc finger 1. | Unc-51 like kinase 3. | 0.918 |
| GLI2 | CUL3 | ENSPPYP00000014260 | ENSPPYP00000014786 | GLI2 isoform 1. | CUL3 isoform 1; Belongs to the cullin family. | 0.968 |
| GLI2 | GLI1 | ENSPPYP00000014260 | ENSPPYP00000005342 | GLI2 isoform 1. | GLI family zinc finger 1. | 0.991 |
| GLI2 | GLI3 | ENSPPYP00000014260 | ENSPPYP00000019741 | GLI2 isoform 1. | GLI3 isoform 3. | 0.984 |
| GLI2 | KIF7 | ENSPPYP00000014260 | ENSPPYP00000007677 | GLI2 isoform 1. | KIF7 isoform 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.965 |
