| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| HRAS | KRAS | ENSPPYP00000003333 | ENSPPYP00000004987 | HRas proto-oncogene, GTPase. | KRAS proto-oncogene, GTPase. | 0.997 |
| HRAS | NRAS | ENSPPYP00000003333 | ENSPPYP00000001163 | HRas proto-oncogene, GTPase. | GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. | 0.997 |
| HRAS | PPP1CB | ENSPPYP00000003333 | ENSPPYP00000013994 | HRas proto-oncogene, GTPase. | Serine/threonine-protein phosphatase PP1-beta catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progressi [...] | 0.416 |
| HRAS | RAF1 | ENSPPYP00000003333 | ENSPPYP00000014975 | HRas proto-oncogene, GTPase. | RAF proto-oncogene serine/threonine-protein kinase; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal- regulated kin [...] | 0.996 |
| HRAS | SHOC2 | ENSPPYP00000003333 | ENSPPYP00000003088 | HRas proto-oncogene, GTPase. | Leucine-rich repeat protein SHOC-2; Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes. | 0.986 |
| KRAS | HRAS | ENSPPYP00000004987 | ENSPPYP00000003333 | KRAS proto-oncogene, GTPase. | HRas proto-oncogene, GTPase. | 0.997 |
| KRAS | NRAS | ENSPPYP00000004987 | ENSPPYP00000001163 | KRAS proto-oncogene, GTPase. | GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. | 0.997 |
| KRAS | PPP1CA | ENSPPYP00000004987 | ENSPPYP00000003472 | KRAS proto-oncogene, GTPase. | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. | 0.931 |
| KRAS | PPP1CB | ENSPPYP00000004987 | ENSPPYP00000013994 | KRAS proto-oncogene, GTPase. | Serine/threonine-protein phosphatase PP1-beta catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progressi [...] | 0.409 |
| KRAS | RAF1 | ENSPPYP00000004987 | ENSPPYP00000014975 | KRAS proto-oncogene, GTPase. | RAF proto-oncogene serine/threonine-protein kinase; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal- regulated kin [...] | 0.999 |
| KRAS | SHOC2 | ENSPPYP00000004987 | ENSPPYP00000003088 | KRAS proto-oncogene, GTPase. | Leucine-rich repeat protein SHOC-2; Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes. | 0.989 |
| MRAS | PPP1CA | ENSPPYP00000015821 | ENSPPYP00000003472 | Muscle RAS oncogene homolog. | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. | 0.929 |
| MRAS | PPP1CB | ENSPPYP00000015821 | ENSPPYP00000013994 | Muscle RAS oncogene homolog. | Serine/threonine-protein phosphatase PP1-beta catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progressi [...] | 0.894 |
| MRAS | PPP1CC | ENSPPYP00000015821 | ENSPPYP00000005654 | Muscle RAS oncogene homolog. | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. | 0.902 |
| MRAS | RAF1 | ENSPPYP00000015821 | ENSPPYP00000014975 | Muscle RAS oncogene homolog. | RAF proto-oncogene serine/threonine-protein kinase; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal- regulated kin [...] | 0.989 |
| MRAS | SHOC2 | ENSPPYP00000015821 | ENSPPYP00000003088 | Muscle RAS oncogene homolog. | Leucine-rich repeat protein SHOC-2; Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes. | 0.992 |
| NRAS | HRAS | ENSPPYP00000001163 | ENSPPYP00000003333 | GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. | HRas proto-oncogene, GTPase. | 0.997 |
| NRAS | KRAS | ENSPPYP00000001163 | ENSPPYP00000004987 | GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. | KRAS proto-oncogene, GTPase. | 0.997 |
| NRAS | PPP1CA | ENSPPYP00000001163 | ENSPPYP00000003472 | GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. | 0.420 |
| NRAS | PPP1CB | ENSPPYP00000001163 | ENSPPYP00000013994 | GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. | Serine/threonine-protein phosphatase PP1-beta catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progressi [...] | 0.423 |
