Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
VTI1AVesicle transport through interaction with t-SNAREs 1A. (217 aa)    
Predicted Functional Partners:
STX6
Syntaxin-6; Involved in intracellular vesicle trafficking.
   
 0.999
VAMP4
VAMP4 isoform 1.
   
 0.999
STX16
STX16-NPEPL1 isoform 1; Belongs to the syntaxin family.
   
 0.998
VAMP3
Vesicle associated membrane protein 3.
   
 0.989
VTI1B
Vesicle transport through interaction with t-SNAREs 1B.
   
0.989
STX8
STX8 isoform 2.
   
 0.989
YKT6
YKT6 v-SNARE homolog; Belongs to the synaptobrevin family.
    
 0.987
STX7
Syntaxin-7; May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes (By similarity).
   
 0.986
STX12
Syntaxin-12; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity). Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity).
   
 0.983
NAPG
NAPG isoform 3.
   
 0.978
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
Server load: low (24%) [HD]