BAG3 protein (Pongo abelii) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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proteins of unknown 3D structure

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gene co-occurrence

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Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAG1	BAG2	ENSPPYP00000021443	ENSPPYP00000018729	BAG1 isoform 2.	BCL2 associated athanogene 2.	0.980
BAG1	BAG3	ENSPPYP00000021443	ENSPPYP00000003157	BAG1 isoform 2.	BAG3 isoform 1.	0.805
BAG1	ENSPPYP00000005659	ENSPPYP00000021443	ENSPPYP00000005659	BAG1 isoform 2.	annotation not available	0.897
BAG1	HSPA1A	ENSPPYP00000021443	ENSPPYP00000018408	BAG1 isoform 2.	Heat shock 70 kDa protein 1; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP [...]	0.800
BAG1	HSPA2	ENSPPYP00000021443	ENSPPYP00000006709	BAG1 isoform 2.	Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family.	0.790
BAG1	HSPA4	ENSPPYP00000021443	ENSPPYP00000017643	BAG1 isoform 2.	Heat shock 70 kDa protein 4; Belongs to the heat shock protein 70 family.	0.974
BAG1	HSPA8	ENSPPYP00000021443	ENSPPYP00000004564	BAG1 isoform 2.	Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...]	0.897
BAG1	STUB1	ENSPPYP00000021443	ENSPPYP00000007837	BAG1 isoform 2.	STIP1 homology and U-box containing protein 1.	0.945
BAG2	BAG1	ENSPPYP00000018729	ENSPPYP00000021443	BCL2 associated athanogene 2.	BAG1 isoform 2.	0.980
BAG2	BAG3	ENSPPYP00000018729	ENSPPYP00000003157	BCL2 associated athanogene 2.	BAG3 isoform 1.	0.871
BAG2	DNAJB6	ENSPPYP00000018729	ENSPPYP00000020432	BCL2 associated athanogene 2.	DnaJ homolog subfamily B member 6; Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins (By similarity). Has a stimulatory effect on the ATPase activity of HSP70 in a dose- dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity (By similarity).	0.817
BAG2	ENSPPYP00000005659	ENSPPYP00000018729	ENSPPYP00000005659	BCL2 associated athanogene 2.	annotation not available	0.909
BAG2	HSPA1A	ENSPPYP00000018729	ENSPPYP00000018408	BCL2 associated athanogene 2.	Heat shock 70 kDa protein 1; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP [...]	0.811
BAG2	HSPA2	ENSPPYP00000018729	ENSPPYP00000006709	BCL2 associated athanogene 2.	Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family.	0.797
BAG2	HSPA4	ENSPPYP00000018729	ENSPPYP00000017643	BCL2 associated athanogene 2.	Heat shock 70 kDa protein 4; Belongs to the heat shock protein 70 family.	0.919
BAG2	HSPA8	ENSPPYP00000018729	ENSPPYP00000004564	BCL2 associated athanogene 2.	Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...]	0.909
BAG2	STUB1	ENSPPYP00000018729	ENSPPYP00000007837	BCL2 associated athanogene 2.	STIP1 homology and U-box containing protein 1.	0.911
BAG3	BAG1	ENSPPYP00000003157	ENSPPYP00000021443	BAG3 isoform 1.	BAG1 isoform 2.	0.805
BAG3	BAG2	ENSPPYP00000003157	ENSPPYP00000018729	BAG3 isoform 1.	BCL2 associated athanogene 2.	0.871
BAG3	DNAJB6	ENSPPYP00000003157	ENSPPYP00000020432	BAG3 isoform 1.	DnaJ homolog subfamily B member 6; Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins (By similarity). Has a stimulatory effect on the ATPase activity of HSP70 in a dose- dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity (By similarity).	0.845