| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANAPC1 | ANAPC5 | ENSPPYP00000013557 | ENSPPYP00000005751 | ANAPC1 isoform 2. | Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). | 0.999 |
| ANAPC1 | BUB1 | ENSPPYP00000013557 | ENSPPYP00000013551 | ANAPC1 isoform 2. | BUB1 mitotic checkpoint serine/threonine kinase. | 0.896 |
| ANAPC1 | BUB1B | ENSPPYP00000013557 | ENSPPYP00000007185 | ANAPC1 isoform 2. | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta. | 0.985 |
| ANAPC1 | BUB3 | ENSPPYP00000013557 | ENSPPYP00000003192 | ANAPC1 isoform 2. | Mitotic checkpoint protein BUB3; Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. T [...] | 0.971 |
| ANAPC1 | CDC20 | ENSPPYP00000013557 | ENSPPYP00000001678 | ANAPC1 isoform 2. | Cell division cycle 20. | 0.999 |
| ANAPC1 | CDC23 | ENSPPYP00000013557 | ENSPPYP00000017692 | ANAPC1 isoform 2. | Cell division cycle 23. | 0.999 |
| ANAPC1 | CDC27 | ENSPPYP00000013557 | ENSPPYP00000010040 | ANAPC1 isoform 2. | CDC27 isoform 1. | 0.999 |
| ANAPC1 | MAD1L1 | ENSPPYP00000013557 | ENSPPYP00000019395 | ANAPC1 isoform 2. | Mitotic arrest deficient 1 like 1. | 0.664 |
| ANAPC1 | MAD2L1 | ENSPPYP00000013557 | ENSPPYP00000016788 | ANAPC1 isoform 2. | MAD2L1 isoform 1. | 0.989 |
| ANAPC1 | ZCCHC4 | ENSPPYP00000013557 | ENSPPYP00000016367 | ANAPC1 isoform 2. | Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). | 0.998 |
| ANAPC5 | ANAPC1 | ENSPPYP00000005751 | ENSPPYP00000013557 | Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). | ANAPC1 isoform 2. | 0.999 |
| ANAPC5 | BUB1 | ENSPPYP00000005751 | ENSPPYP00000013551 | Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). | BUB1 mitotic checkpoint serine/threonine kinase. | 0.889 |
| ANAPC5 | BUB1B | ENSPPYP00000005751 | ENSPPYP00000007185 | Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta. | 0.984 |
| ANAPC5 | BUB3 | ENSPPYP00000005751 | ENSPPYP00000003192 | Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). | Mitotic checkpoint protein BUB3; Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. T [...] | 0.977 |
| ANAPC5 | CDC20 | ENSPPYP00000005751 | ENSPPYP00000001678 | Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). | Cell division cycle 20. | 0.999 |
| ANAPC5 | CDC23 | ENSPPYP00000005751 | ENSPPYP00000017692 | Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). | Cell division cycle 23. | 0.999 |
| ANAPC5 | CDC27 | ENSPPYP00000005751 | ENSPPYP00000010040 | Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). | CDC27 isoform 1. | 0.999 |
| ANAPC5 | MAD1L1 | ENSPPYP00000005751 | ENSPPYP00000019395 | Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). | Mitotic arrest deficient 1 like 1. | 0.720 |
| ANAPC5 | MAD2L1 | ENSPPYP00000005751 | ENSPPYP00000016788 | Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). | MAD2L1 isoform 1. | 0.981 |
| ANAPC5 | ZCCHC4 | ENSPPYP00000005751 | ENSPPYP00000016367 | Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). | Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). | 0.998 |