| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADH1A | ALDH2 | ENSPPYP00000016692 | ENSPPYP00000005665 | Alcohol dehydrogenase 1A. | Aldehyde dehydrogenase, mitochondrial; Is capable of converting retinaldehyde to retinoic acid. Belongs to the aldehyde dehydrogenase family. | 0.871 |
| ADH1A | ALDH3A1 | ENSPPYP00000016692 | ENSPPYP00000009919 | Alcohol dehydrogenase 1A. | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | 0.952 |
| ADH1A | ALDH3A2 | ENSPPYP00000016692 | ENSPPYP00000023716 | Alcohol dehydrogenase 1A. | Aldehyde dehydrogenase family 3 member A2; Catalyzes the oxidation of medium and long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid. | 0.790 |
| ADH1A | CYP2E1 | ENSPPYP00000016692 | ENSPPYP00000003264 | Alcohol dehydrogenase 1A. | CYP2E1 isoform 1; Belongs to the cytochrome P450 family. | 0.941 |
| ADH1A | UGT1A3 | ENSPPYP00000016692 | ENSPPYP00000014864 | Alcohol dehydrogenase 1A. | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.662 |
| ADH1A | UGT2B7 | ENSPPYP00000016692 | ENSPPYP00000016513 | Alcohol dehydrogenase 1A. | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.673 |
| ALDH2 | ADH1A | ENSPPYP00000005665 | ENSPPYP00000016692 | Aldehyde dehydrogenase, mitochondrial; Is capable of converting retinaldehyde to retinoic acid. Belongs to the aldehyde dehydrogenase family. | Alcohol dehydrogenase 1A. | 0.871 |
| ALDH2 | ALDH3A2 | ENSPPYP00000005665 | ENSPPYP00000023716 | Aldehyde dehydrogenase, mitochondrial; Is capable of converting retinaldehyde to retinoic acid. Belongs to the aldehyde dehydrogenase family. | Aldehyde dehydrogenase family 3 member A2; Catalyzes the oxidation of medium and long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid. | 0.914 |
| ALDH2 | CYP2E1 | ENSPPYP00000005665 | ENSPPYP00000003264 | Aldehyde dehydrogenase, mitochondrial; Is capable of converting retinaldehyde to retinoic acid. Belongs to the aldehyde dehydrogenase family. | CYP2E1 isoform 1; Belongs to the cytochrome P450 family. | 0.951 |
| ALDH3A1 | ADH1A | ENSPPYP00000009919 | ENSPPYP00000016692 | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | Alcohol dehydrogenase 1A. | 0.952 |
| ALDH3A1 | CYP2E1 | ENSPPYP00000009919 | ENSPPYP00000003264 | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | CYP2E1 isoform 1; Belongs to the cytochrome P450 family. | 0.946 |
| ALDH3A1 | EPHX1 | ENSPPYP00000009919 | ENSPPYP00000000173 | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family. | 0.403 |
| ALDH3A1 | UGT1A3 | ENSPPYP00000009919 | ENSPPYP00000014864 | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.450 |
| ALDH3A2 | ADH1A | ENSPPYP00000023716 | ENSPPYP00000016692 | Aldehyde dehydrogenase family 3 member A2; Catalyzes the oxidation of medium and long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid. | Alcohol dehydrogenase 1A. | 0.790 |
| ALDH3A2 | ALDH2 | ENSPPYP00000023716 | ENSPPYP00000005665 | Aldehyde dehydrogenase family 3 member A2; Catalyzes the oxidation of medium and long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid. | Aldehyde dehydrogenase, mitochondrial; Is capable of converting retinaldehyde to retinoic acid. Belongs to the aldehyde dehydrogenase family. | 0.914 |
| ALDH3A2 | CYP2E1 | ENSPPYP00000023716 | ENSPPYP00000003264 | Aldehyde dehydrogenase family 3 member A2; Catalyzes the oxidation of medium and long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid. | CYP2E1 isoform 1; Belongs to the cytochrome P450 family. | 0.949 |
| ALDH3A2 | EPHX1 | ENSPPYP00000023716 | ENSPPYP00000000173 | Aldehyde dehydrogenase family 3 member A2; Catalyzes the oxidation of medium and long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid. | Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family. | 0.540 |
| ALDH3A2 | UGT1A3 | ENSPPYP00000023716 | ENSPPYP00000014864 | Aldehyde dehydrogenase family 3 member A2; Catalyzes the oxidation of medium and long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid. | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.670 |
| ALDH3A2 | UGT2B7 | ENSPPYP00000023716 | ENSPPYP00000016513 | Aldehyde dehydrogenase family 3 member A2; Catalyzes the oxidation of medium and long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid. | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.478 |
| CYP1A2 | CYP2E1 | ENSPPYP00000007537 | ENSPPYP00000003264 | Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] | CYP2E1 isoform 1; Belongs to the cytochrome P450 family. | 0.951 |
