SHLD2 protein (Pongo abelii) - STRING interaction network

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SHLD2

Shieldin complex subunit 2; Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres. (904 aa)

Predicted Functional Partners:

MAD2L2

0.903

CTC1

0.727

SHLD1

0.704

PAXX

0.619

POLQ

0.551

C20orf96

0.486

TP53BP1

0.473

RAD52

0.423

REV3L

0.410

SDF2L1

0.408

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C20orf96	SHLD1	ENSPPYP00000012142	ENSPPYP00000023737	C20orf96 isoform 2.	C20orf196 isoform 1.	0.485
C20orf96	SHLD2	ENSPPYP00000012142	ENSPPYP00000003293	C20orf96 isoform 2.	Shieldin complex subunit 2; Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres.	0.486
CTC1	PAXX	ENSPPYP00000008942	ENSPPYP00000022199	CST complex subunit CTC1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST comp [...]	PAXX non-homologous end joining factor.	0.587
CTC1	POLQ	ENSPPYP00000008942	ENSPPYP00000015096	CST complex subunit CTC1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST comp [...]	POLQ isoform 2.	0.455
CTC1	REV3L	ENSPPYP00000008942	ENSPPYP00000018949	CST complex subunit CTC1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST comp [...]	REV3L isoform 3.	0.474
CTC1	SHLD1	ENSPPYP00000008942	ENSPPYP00000023737	CST complex subunit CTC1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST comp [...]	C20orf196 isoform 1.	0.757
CTC1	SHLD2	ENSPPYP00000008942	ENSPPYP00000003293	CST complex subunit CTC1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST comp [...]	Shieldin complex subunit 2; Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres.	0.727
CTC1	TP53BP1	ENSPPYP00000008942	ENSPPYP00000007267	CST complex subunit CTC1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST comp [...]	TP53BP1 isoform 3.	0.475
MAD2L2	RAD52	ENSPPYP00000002184	ENSPPYP00000004716	Mitotic arrest deficient 2 like 2.	RAD52 homolog, DNA repair protein.	0.431
MAD2L2	REV3L	ENSPPYP00000002184	ENSPPYP00000018949	Mitotic arrest deficient 2 like 2.	REV3L isoform 3.	0.999
MAD2L2	SHLD1	ENSPPYP00000002184	ENSPPYP00000023737	Mitotic arrest deficient 2 like 2.	C20orf196 isoform 1.	0.592
MAD2L2	SHLD2	ENSPPYP00000002184	ENSPPYP00000003293	Mitotic arrest deficient 2 like 2.	Shieldin complex subunit 2; Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres.	0.903
MAD2L2	TP53BP1	ENSPPYP00000002184	ENSPPYP00000007267	Mitotic arrest deficient 2 like 2.	TP53BP1 isoform 3.	0.857
PAXX	CTC1	ENSPPYP00000022199	ENSPPYP00000008942	PAXX non-homologous end joining factor.	CST complex subunit CTC1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST comp [...]	0.587
PAXX	SHLD2	ENSPPYP00000022199	ENSPPYP00000003293	PAXX non-homologous end joining factor.	Shieldin complex subunit 2; Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres.	0.619
PAXX	TP53BP1	ENSPPYP00000022199	ENSPPYP00000007267	PAXX non-homologous end joining factor.	TP53BP1 isoform 3.	0.537
POLQ	CTC1	ENSPPYP00000015096	ENSPPYP00000008942	POLQ isoform 2.	CST complex subunit CTC1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST comp [...]	0.455
POLQ	RAD52	ENSPPYP00000015096	ENSPPYP00000004716	POLQ isoform 2.	RAD52 homolog, DNA repair protein.	0.556
POLQ	SHLD1	ENSPPYP00000015096	ENSPPYP00000023737	POLQ isoform 2.	C20orf196 isoform 1.	0.485
POLQ	SHLD2	ENSPPYP00000015096	ENSPPYP00000003293	POLQ isoform 2.	Shieldin complex subunit 2; Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres.	0.551

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