Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TOLLIPToll interacting protein. (274 aa)    
Predicted Functional Partners:
IRAK1
Interleukin 1 receptor associated kinase 1.
    
 0.974
TOM1
TOM1 isoform 6; Belongs to the TOM1 family.
   
 
 0.968
MYD88
Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.
   
 0.956
TLR2
Toll-like receptor.
    
 0.951
TOM1L2
TOM1L2 isoform 8; Belongs to the TOM1 family.
   
 
 0.947
TOM1L1
TOM1L1 isoform 12; Belongs to the TOM1 family.
    
 
 0.938
IRAK4
IRAK4 isoform 6.
    
 0.918
TRAF6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
    
 0.876
IL1R1
Interleukin 1 receptor type 1.
    
 0.876
IRAK2
Interleukin-1 receptor-associated kinase-like 2; Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.
    
 0.874
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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