| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CASP10 | CASP8 | ENSPPYP00000014602 | ENSPPYP00000014605 | CASP10 isoform 3; Belongs to the peptidase C14A family. | CASP8 isoform 1; Belongs to the peptidase C14A family. | 0.997 |
| CASP10 | CFLAR | ENSPPYP00000014602 | ENSPPYP00000014600 | CASP10 isoform 3; Belongs to the peptidase C14A family. | CASP8 and FADD-like apoptosis regulator subunit p12; Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity (By similarity). Belongs to [...] | 0.997 |
| CASP10 | CR201_G0015089 | ENSPPYP00000014602 | ENSPPYP00000008406 | CASP10 isoform 3; Belongs to the peptidase C14A family. | TRADD isoform 2. | 0.926 |
| CASP10 | FADD | ENSPPYP00000014602 | ENSPPYP00000003427 | CASP10 isoform 3; Belongs to the peptidase C14A family. | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | 0.999 |
| CASP10 | FASLG | ENSPPYP00000014602 | ENSPPYP00000000581 | CASP10 isoform 3; Belongs to the peptidase C14A family. | FASLG isoform 1; Belongs to the tumor necrosis factor family. | 0.965 |
| CASP10 | RIPK1 | ENSPPYP00000014602 | ENSPPYP00000018096 | CASP10 isoform 3; Belongs to the peptidase C14A family. | Receptor interacting serine/threonine kinase 1. | 0.966 |
| CASP10 | RIPK3 | ENSPPYP00000014602 | ENSPPYP00000006485 | CASP10 isoform 3; Belongs to the peptidase C14A family. | Receptor interacting serine/threonine kinase 3. | 0.949 |
| CASP10 | TNFRSF10A | ENSPPYP00000014602 | ENSPPYP00000020658 | CASP10 isoform 3; Belongs to the peptidase C14A family. | TNFRSF10A isoform 1. | 0.778 |
| CASP10 | TNFRSF10B | ENSPPYP00000014602 | ENSPPYP00000020655 | CASP10 isoform 3; Belongs to the peptidase C14A family. | TNFRSF10B isoform 3. | 0.872 |
| CASP10 | TNFRSF1A | ENSPPYP00000014602 | ENSPPYP00000004766 | CASP10 isoform 3; Belongs to the peptidase C14A family. | TNFRSF1A isoform 2. | 0.813 |
| CASP8 | CASP10 | ENSPPYP00000014605 | ENSPPYP00000014602 | CASP8 isoform 1; Belongs to the peptidase C14A family. | CASP10 isoform 3; Belongs to the peptidase C14A family. | 0.997 |
| CASP8 | CFLAR | ENSPPYP00000014605 | ENSPPYP00000014600 | CASP8 isoform 1; Belongs to the peptidase C14A family. | CASP8 and FADD-like apoptosis regulator subunit p12; Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity (By similarity). Belongs to [...] | 0.998 |
| CASP8 | CR201_G0015089 | ENSPPYP00000014605 | ENSPPYP00000008406 | CASP8 isoform 1; Belongs to the peptidase C14A family. | TRADD isoform 2. | 0.979 |
| CASP8 | FADD | ENSPPYP00000014605 | ENSPPYP00000003427 | CASP8 isoform 1; Belongs to the peptidase C14A family. | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | 0.999 |
| CASP8 | FASLG | ENSPPYP00000014605 | ENSPPYP00000000581 | CASP8 isoform 1; Belongs to the peptidase C14A family. | FASLG isoform 1; Belongs to the tumor necrosis factor family. | 0.990 |
| CASP8 | RIPK1 | ENSPPYP00000014605 | ENSPPYP00000018096 | CASP8 isoform 1; Belongs to the peptidase C14A family. | Receptor interacting serine/threonine kinase 1. | 0.999 |
| CASP8 | RIPK3 | ENSPPYP00000014605 | ENSPPYP00000006485 | CASP8 isoform 1; Belongs to the peptidase C14A family. | Receptor interacting serine/threonine kinase 3. | 0.998 |
| CASP8 | TNFRSF10A | ENSPPYP00000014605 | ENSPPYP00000020658 | CASP8 isoform 1; Belongs to the peptidase C14A family. | TNFRSF10A isoform 1. | 0.976 |
| CASP8 | TNFRSF10B | ENSPPYP00000014605 | ENSPPYP00000020655 | CASP8 isoform 1; Belongs to the peptidase C14A family. | TNFRSF10B isoform 3. | 0.979 |
| CASP8 | TNFRSF1A | ENSPPYP00000014605 | ENSPPYP00000004766 | CASP8 isoform 1; Belongs to the peptidase C14A family. | TNFRSF1A isoform 2. | 0.869 |
