| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ASH1L | CAMKMT | ENSPPYP00000000864 | ENSPPYP00000013903 | ASH1L isoform 2. | CAMKMT isoform 1. | 0.694 |
| ASH1L | DYRK1A | ENSPPYP00000000864 | ENSPPYP00000012738 | ASH1L isoform 2. | DYRK1A isoform 7. | 0.574 |
| ASH1L | KMT5B | ENSPPYP00000000864 | ENSPPYP00000003448 | ASH1L isoform 2. | Lysine methyltransferase 5B. | 0.543 |
| BRD4 | CBX3 | ENSPPYP00000010837 | ENSPPYP00000019856 | Bromodomain containing 4. | Chromobox protein homolog 3; Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the [...] | 0.863 |
| BRD4 | H2AZ1 | ENSPPYP00000010837 | ENSPPYP00000016702 | Bromodomain containing 4. | Histone H2A.Z; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for c [...] | 0.545 |
| BRD4 | H2AZ2 | ENSPPYP00000010837 | ENSPPYP00000019708 | Bromodomain containing 4. | Histone H2A; Belongs to the histone H2A family. | 0.545 |
| BRD4 | H4C7 | ENSPPYP00000010837 | ENSPPYP00000018250 | Bromodomain containing 4. | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.683 |
| BRD4 | KMT5B | ENSPPYP00000010837 | ENSPPYP00000003448 | Bromodomain containing 4. | Lysine methyltransferase 5B. | 0.741 |
| CAMKMT | ASH1L | ENSPPYP00000013903 | ENSPPYP00000000864 | CAMKMT isoform 1. | ASH1L isoform 2. | 0.694 |
| CAMKMT | KMT5B | ENSPPYP00000013903 | ENSPPYP00000003448 | CAMKMT isoform 1. | Lysine methyltransferase 5B. | 0.704 |
| CBX3 | BRD4 | ENSPPYP00000019856 | ENSPPYP00000010837 | Chromobox protein homolog 3; Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the [...] | Bromodomain containing 4. | 0.863 |
| CBX3 | H2AZ1 | ENSPPYP00000019856 | ENSPPYP00000016702 | Chromobox protein homolog 3; Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the [...] | Histone H2A.Z; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for c [...] | 0.678 |
| CBX3 | H2AZ2 | ENSPPYP00000019856 | ENSPPYP00000019708 | Chromobox protein homolog 3; Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the [...] | Histone H2A; Belongs to the histone H2A family. | 0.678 |
| CBX3 | H4C7 | ENSPPYP00000019856 | ENSPPYP00000018250 | Chromobox protein homolog 3; Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the [...] | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.672 |
| CBX3 | KMT5B | ENSPPYP00000019856 | ENSPPYP00000003448 | Chromobox protein homolog 3; Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the [...] | Lysine methyltransferase 5B. | 0.572 |
| DYRK1A | ASH1L | ENSPPYP00000012738 | ENSPPYP00000000864 | DYRK1A isoform 7. | ASH1L isoform 2. | 0.574 |
| DYRK1A | KMT5B | ENSPPYP00000012738 | ENSPPYP00000003448 | DYRK1A isoform 7. | Lysine methyltransferase 5B. | 0.571 |
| H2AZ1 | BRD4 | ENSPPYP00000016702 | ENSPPYP00000010837 | Histone H2A.Z; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for c [...] | Bromodomain containing 4. | 0.545 |
| H2AZ1 | CBX3 | ENSPPYP00000016702 | ENSPPYP00000019856 | Histone H2A.Z; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for c [...] | Chromobox protein homolog 3; Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the [...] | 0.678 |
| H2AZ1 | H2AZ2 | ENSPPYP00000016702 | ENSPPYP00000019708 | Histone H2A.Z; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for c [...] | Histone H2A; Belongs to the histone H2A family. | 0.991 |
