| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ENSPPYP00000012086 | IRAK2 | ENSPPYP00000012086 | ENSPPYP00000015274 | annotation not available | Interleukin-1 receptor-associated kinase-like 2; Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. | 0.405 |
| ENSPPYP00000012086 | IRAK4 | ENSPPYP00000012086 | ENSPPYP00000005053 | annotation not available | IRAK4 isoform 6. | 0.428 |
| ENSPPYP00000012086 | PELI1 | ENSPPYP00000012086 | ENSPPYP00000013792 | annotation not available | E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. | 0.651 |
| ENSPPYP00000012086 | PELI3 | ENSPPYP00000012086 | ENSPPYP00000003501 | annotation not available | E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. | 0.651 |
| ENSPPYP00000012086 | TMEM189-UBE2V1 | ENSPPYP00000012086 | ENSPPYP00000012429 | annotation not available | Ubiquitin-conjugating enzyme E2 variant 1; Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly- ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF- kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repa [...] | 0.981 |
| ENSPPYP00000012086 | TRAF6 | ENSPPYP00000012086 | ENSPPYP00000003845 | annotation not available | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.587 |
| ENSPPYP00000012086 | UBE2N | ENSPPYP00000012086 | ENSPPYP00000005510 | annotation not available | Ubiquitin-conjugating enzyme E2 N; The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly- ubiquitination of [...] | 0.912 |
| IRAK1 | IRAK2 | ENSPPYP00000023353 | ENSPPYP00000015274 | Interleukin 1 receptor associated kinase 1. | Interleukin-1 receptor-associated kinase-like 2; Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. | 0.991 |
| IRAK1 | IRAK4 | ENSPPYP00000023353 | ENSPPYP00000005053 | Interleukin 1 receptor associated kinase 1. | IRAK4 isoform 6. | 0.999 |
| IRAK1 | MAP3K7 | ENSPPYP00000023353 | ENSPPYP00000018861 | Interleukin 1 receptor associated kinase 1. | Mitogen-activated protein kinase kinase kinase 7; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as a [...] | 0.991 |
| IRAK1 | PELI1 | ENSPPYP00000023353 | ENSPPYP00000013792 | Interleukin 1 receptor associated kinase 1. | E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. | 0.980 |
| IRAK1 | PELI3 | ENSPPYP00000023353 | ENSPPYP00000003501 | Interleukin 1 receptor associated kinase 1. | E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. | 0.970 |
| IRAK1 | RIPK1 | ENSPPYP00000023353 | ENSPPYP00000018096 | Interleukin 1 receptor associated kinase 1. | Receptor interacting serine/threonine kinase 1. | 0.406 |
| IRAK1 | TRAF6 | ENSPPYP00000023353 | ENSPPYP00000003845 | Interleukin 1 receptor associated kinase 1. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.999 |
| IRAK1 | UBE2N | ENSPPYP00000023353 | ENSPPYP00000005510 | Interleukin 1 receptor associated kinase 1. | Ubiquitin-conjugating enzyme E2 N; The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly- ubiquitination of [...] | 0.581 |
| IRAK2 | ENSPPYP00000012086 | ENSPPYP00000015274 | ENSPPYP00000012086 | Interleukin-1 receptor-associated kinase-like 2; Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. | annotation not available | 0.405 |
| IRAK2 | IRAK1 | ENSPPYP00000015274 | ENSPPYP00000023353 | Interleukin-1 receptor-associated kinase-like 2; Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. | Interleukin 1 receptor associated kinase 1. | 0.991 |
| IRAK2 | IRAK4 | ENSPPYP00000015274 | ENSPPYP00000005053 | Interleukin-1 receptor-associated kinase-like 2; Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. | IRAK4 isoform 6. | 0.995 |
| IRAK2 | MAP3K7 | ENSPPYP00000015274 | ENSPPYP00000018861 | Interleukin-1 receptor-associated kinase-like 2; Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. | Mitogen-activated protein kinase kinase kinase 7; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as a [...] | 0.863 |
| IRAK2 | PELI1 | ENSPPYP00000015274 | ENSPPYP00000013792 | Interleukin-1 receptor-associated kinase-like 2; Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. | E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. | 0.676 |
