| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATM | KAT5 | ENSPPYP00000004403 | ENSPPYP00000003532 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Histone acetyltransferase KAT5; Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replica [...] | 0.990 |
| ATM | TRRAP | ENSPPYP00000004403 | ENSPPYP00000019457 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Transformation/transcription domain associated protein; Belongs to the PI3/PI4-kinase family. | 0.492 |
| CR201_G0017535 | CR201_G0052208 | ENSPPYP00000017690 | ENSPPYP00000012531 | BRD8 isoform 7. | MRGBP isoform 1. | 0.988 |
| CR201_G0017535 | DMAP1 | ENSPPYP00000017690 | ENSPPYP00000001660 | BRD8 isoform 7. | DNA methyltransferase 1 associated protein 1. | 0.989 |
| CR201_G0017535 | EP400 | ENSPPYP00000017690 | ENSPPYP00000005850 | BRD8 isoform 7. | EP400 isoform 3. | 0.988 |
| CR201_G0017535 | ING3 | ENSPPYP00000017690 | ENSPPYP00000020124 | BRD8 isoform 7. | Inhibitor of growth protein 3; Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicat [...] | 0.974 |
| CR201_G0017535 | KAT5 | ENSPPYP00000017690 | ENSPPYP00000003532 | BRD8 isoform 7. | Histone acetyltransferase KAT5; Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replica [...] | 0.987 |
| CR201_G0017535 | MEAF6 | ENSPPYP00000017690 | ENSPPYP00000001769 | BRD8 isoform 7. | MYST/Esa1 associated factor 6. | 0.985 |
| CR201_G0017535 | RUVBL1 | ENSPPYP00000017690 | ENSPPYP00000015029 | BRD8 isoform 7. | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. | 0.979 |
| CR201_G0017535 | RUVBL2 | ENSPPYP00000017690 | ENSPPYP00000011437 | BRD8 isoform 7. | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. | 0.980 |
| CR201_G0017535 | TRRAP | ENSPPYP00000017690 | ENSPPYP00000019457 | BRD8 isoform 7. | Transformation/transcription domain associated protein; Belongs to the PI3/PI4-kinase family. | 0.986 |
| CR201_G0052208 | CR201_G0017535 | ENSPPYP00000012531 | ENSPPYP00000017690 | MRGBP isoform 1. | BRD8 isoform 7. | 0.988 |
| CR201_G0052208 | DMAP1 | ENSPPYP00000012531 | ENSPPYP00000001660 | MRGBP isoform 1. | DNA methyltransferase 1 associated protein 1. | 0.989 |
| CR201_G0052208 | EP400 | ENSPPYP00000012531 | ENSPPYP00000005850 | MRGBP isoform 1. | EP400 isoform 3. | 0.991 |
| CR201_G0052208 | ING3 | ENSPPYP00000012531 | ENSPPYP00000020124 | MRGBP isoform 1. | Inhibitor of growth protein 3; Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicat [...] | 0.993 |
| CR201_G0052208 | KAT5 | ENSPPYP00000012531 | ENSPPYP00000003532 | MRGBP isoform 1. | Histone acetyltransferase KAT5; Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replica [...] | 0.988 |
| CR201_G0052208 | MEAF6 | ENSPPYP00000012531 | ENSPPYP00000001769 | MRGBP isoform 1. | MYST/Esa1 associated factor 6. | 0.988 |
| CR201_G0052208 | RUVBL1 | ENSPPYP00000012531 | ENSPPYP00000015029 | MRGBP isoform 1. | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. | 0.981 |
| CR201_G0052208 | RUVBL2 | ENSPPYP00000012531 | ENSPPYP00000011437 | MRGBP isoform 1. | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. | 0.981 |
| CR201_G0052208 | TRRAP | ENSPPYP00000012531 | ENSPPYP00000019457 | MRGBP isoform 1. | Transformation/transcription domain associated protein; Belongs to the PI3/PI4-kinase family. | 0.989 |
