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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CAPN1Calpain-1 catalytic subunit; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. (714 aa)    
Predicted Functional Partners:
CAPNS1
CAPNS1 isoform 1.
   
0.988
CAST
CAST isoform 3.
   
 0.979
CDK5R1
Cyclin-dependent kinase 5 activator.
   
 
 0.950
BAK1
Bcl-2 homologous antagonist/killer.
   
 0.923
CR201_G0025521
CASP12 isoform 3; Belongs to the peptidase C14A family.
   
 0.912
BID-2
BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.
   
  0.908
IL1A
Interleukin-1; Belongs to the IL-1 family.
   
 
 0.906
CAPN8
CAPN8 isoform 1; Belongs to the peptidase C2 family.
  
0.799
CAPN2
CAPN2 isoform 2; Belongs to the peptidase C2 family.
  
0.717
PYGM
Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
   
  
 0.600
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.