| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABCC4 | PDZK1 | ENSPPYP00000006208 | ENSPPYP00000001092 | ABCC4 isoform 3. | Na(+)/H(+) exchange regulatory cofactor NHE-RF3; A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resista [...] | 0.599 |
| ABCC4 | SLC17A1 | ENSPPYP00000006208 | ENSPPYP00000018222 | ABCC4 isoform 3. | Solute carrier family 17 member 1. | 0.729 |
| ABCC4 | SLC22A11 | ENSPPYP00000006208 | ENSPPYP00000003588 | ABCC4 isoform 3. | SLC22A11 isoform 1. | 0.495 |
| NEDD4L | SLC22A11 | ENSPPYP00000010317 | ENSPPYP00000003588 | E3 ubiquitin-protein ligase NEDD4-like; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF- beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, KCNH2, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiq [...] | SLC22A11 isoform 1. | 0.538 |
| PDZK1 | ABCC4 | ENSPPYP00000001092 | ENSPPYP00000006208 | Na(+)/H(+) exchange regulatory cofactor NHE-RF3; A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resista [...] | ABCC4 isoform 3. | 0.599 |
| PDZK1 | SLC16A9 | ENSPPYP00000001092 | ENSPPYP00000002813 | Na(+)/H(+) exchange regulatory cofactor NHE-RF3; A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resista [...] | Monocarboxylate transporter 9; Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane. Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. | 0.487 |
| PDZK1 | SLC17A1 | ENSPPYP00000001092 | ENSPPYP00000018222 | Na(+)/H(+) exchange regulatory cofactor NHE-RF3; A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resista [...] | Solute carrier family 17 member 1. | 0.627 |
| PDZK1 | SLC22A11 | ENSPPYP00000001092 | ENSPPYP00000003588 | Na(+)/H(+) exchange regulatory cofactor NHE-RF3; A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resista [...] | SLC22A11 isoform 1. | 0.553 |
| PDZK1 | SLC2A9 | ENSPPYP00000001092 | ENSPPYP00000016315 | Na(+)/H(+) exchange regulatory cofactor NHE-RF3; A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resista [...] | Solute carrier family 2, facilitated glucose transporter member 9; Urate transporter, which may play a role in the urate reabsorption by proximal tubules (By similarity). Does not transport glucose, fructose or galactose (By similarity). | 0.476 |
| SLC16A5 | SLC22A11 | ENSPPYP00000009677 | ENSPPYP00000003588 | Solute carrier family 16 member 5. | SLC22A11 isoform 1. | 0.692 |
| SLC16A5 | SLC38A10 | ENSPPYP00000009677 | ENSPPYP00000009800 | Solute carrier family 16 member 5. | Putative sodium-coupled neutral amino acid transporter 10; Putative sodium-dependent amino acid/proton antiporter. Belongs to the amino acid/polyamine transporter 2 family. | 0.868 |
| SLC16A6 | SLC22A11 | ENSPPYP00000009629 | ENSPPYP00000003588 | Solute carrier family 16 member 6. | SLC22A11 isoform 1. | 0.727 |
| SLC16A6 | SLC38A10 | ENSPPYP00000009629 | ENSPPYP00000009800 | Solute carrier family 16 member 6. | Putative sodium-coupled neutral amino acid transporter 10; Putative sodium-dependent amino acid/proton antiporter. Belongs to the amino acid/polyamine transporter 2 family. | 0.671 |
| SLC16A9 | PDZK1 | ENSPPYP00000002813 | ENSPPYP00000001092 | Monocarboxylate transporter 9; Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane. Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. | Na(+)/H(+) exchange regulatory cofactor NHE-RF3; A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resista [...] | 0.487 |
| SLC16A9 | SLC17A1 | ENSPPYP00000002813 | ENSPPYP00000018222 | Monocarboxylate transporter 9; Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane. Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. | Solute carrier family 17 member 1. | 0.487 |
| SLC16A9 | SLC22A11 | ENSPPYP00000002813 | ENSPPYP00000003588 | Monocarboxylate transporter 9; Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane. Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. | SLC22A11 isoform 1. | 0.519 |
| SLC16A9 | SLC2A9 | ENSPPYP00000002813 | ENSPPYP00000016315 | Monocarboxylate transporter 9; Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane. Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. | Solute carrier family 2, facilitated glucose transporter member 9; Urate transporter, which may play a role in the urate reabsorption by proximal tubules (By similarity). Does not transport glucose, fructose or galactose (By similarity). | 0.582 |
| SLC17A1 | ABCC4 | ENSPPYP00000018222 | ENSPPYP00000006208 | Solute carrier family 17 member 1. | ABCC4 isoform 3. | 0.729 |
| SLC17A1 | PDZK1 | ENSPPYP00000018222 | ENSPPYP00000001092 | Solute carrier family 17 member 1. | Na(+)/H(+) exchange regulatory cofactor NHE-RF3; A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resista [...] | 0.627 |
| SLC17A1 | SLC16A9 | ENSPPYP00000018222 | ENSPPYP00000002813 | Solute carrier family 17 member 1. | Monocarboxylate transporter 9; Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane. Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. | 0.487 |
