| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CAPN1 | CHRM1 | ENSPPYP00000003556 | ENSPPYP00000003626 | Calpain-1 catalytic subunit; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. | Muscarinic acetylcholine receptor M1; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. | 0.578 |
| CAPN1 | COX8A | ENSPPYP00000003556 | ENSPPYP00000003606 | Calpain-1 catalytic subunit; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. | T0108974 isoform 1. | 0.578 |
| CAPN1 | FKBP2 | ENSPPYP00000003556 | ENSPPYP00000003596 | Calpain-1 catalytic subunit; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. | Peptidylprolyl isomerase. | 0.499 |
| CAPN1 | FOSL1 | ENSPPYP00000003556 | ENSPPYP00000003519 | Calpain-1 catalytic subunit; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. | FOSL1 isoform 2. | 0.575 |
| CAPN1 | MAP3K11 | ENSPPYP00000003556 | ENSPPYP00000003540 | Calpain-1 catalytic subunit; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. | Mitogen-activated protein kinase kinase kinase. | 0.589 |
| CAPN1 | PLCB3 | ENSPPYP00000003556 | ENSPPYP00000003595 | Calpain-1 catalytic subunit; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. | 0.579 |
| CAPN1 | PYGM | ENSPPYP00000003556 | ENSPPYP00000003583 | Calpain-1 catalytic subunit; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. | Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. | 0.600 |
| CAPN1 | ROM1 | ENSPPYP00000003556 | ENSPPYP00000003649 | Calpain-1 catalytic subunit; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. | ROM1 isoform 4. | 0.584 |
| CHRM1 | CAPN1 | ENSPPYP00000003626 | ENSPPYP00000003556 | Muscarinic acetylcholine receptor M1; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. | Calpain-1 catalytic subunit; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. | 0.578 |
| CHRM1 | COX8A | ENSPPYP00000003626 | ENSPPYP00000003606 | Muscarinic acetylcholine receptor M1; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. | T0108974 isoform 1. | 0.578 |
| CHRM1 | FKBP2 | ENSPPYP00000003626 | ENSPPYP00000003596 | Muscarinic acetylcholine receptor M1; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. | Peptidylprolyl isomerase. | 0.499 |
| CHRM1 | FOSL1 | ENSPPYP00000003626 | ENSPPYP00000003519 | Muscarinic acetylcholine receptor M1; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. | FOSL1 isoform 2. | 0.576 |
| CHRM1 | MAP3K11 | ENSPPYP00000003626 | ENSPPYP00000003540 | Muscarinic acetylcholine receptor M1; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. | Mitogen-activated protein kinase kinase kinase. | 0.595 |
| CHRM1 | PLCB3 | ENSPPYP00000003626 | ENSPPYP00000003595 | Muscarinic acetylcholine receptor M1; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. | 0.704 |
| CHRM1 | PYGM | ENSPPYP00000003626 | ENSPPYP00000003583 | Muscarinic acetylcholine receptor M1; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. | Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. | 0.575 |
| CHRM1 | ROM1 | ENSPPYP00000003626 | ENSPPYP00000003649 | Muscarinic acetylcholine receptor M1; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. | ROM1 isoform 4. | 0.583 |
| COX8A | CAPN1 | ENSPPYP00000003606 | ENSPPYP00000003556 | T0108974 isoform 1. | Calpain-1 catalytic subunit; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. | 0.578 |
| COX8A | CHRM1 | ENSPPYP00000003606 | ENSPPYP00000003626 | T0108974 isoform 1. | Muscarinic acetylcholine receptor M1; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. | 0.578 |
| COX8A | FKBP2 | ENSPPYP00000003606 | ENSPPYP00000003596 | T0108974 isoform 1. | Peptidylprolyl isomerase. | 0.508 |
| COX8A | FOSL1 | ENSPPYP00000003606 | ENSPPYP00000003519 | T0108974 isoform 1. | FOSL1 isoform 2. | 0.588 |