| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CR201_G0037390 | FGF1 | ENSPPYP00000010903 | ENSPPYP00000024593 | PIK3R2 isoform 1. | Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with int [...] | 0.514 |
| CR201_G0037390 | FGF17 | ENSPPYP00000010903 | ENSPPYP00000020628 | PIK3R2 isoform 1. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.533 |
| CR201_G0037390 | FGF23 | ENSPPYP00000010903 | ENSPPYP00000005881 | PIK3R2 isoform 1. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.507 |
| CR201_G0037390 | FGF3 | ENSPPYP00000010903 | ENSPPYP00000003430 | PIK3R2 isoform 1. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.534 |
| CR201_G0037390 | FGF4 | ENSPPYP00000010903 | ENSPPYP00000003431 | PIK3R2 isoform 1. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.537 |
| CR201_G0037390 | FGFR1 | ENSPPYP00000010903 | ENSPPYP00000020767 | PIK3R2 isoform 1. | Fibroblast growth factor receptor. | 0.958 |
| CR201_G0037390 | FLRT1 | ENSPPYP00000010903 | ENSPPYP00000003604 | PIK3R2 isoform 1. | Fibronectin leucine rich transmembrane protein 1. | 0.630 |
| CR201_G0037390 | PIK3R1 | ENSPPYP00000010903 | ENSPPYP00000017341 | PIK3R2 isoform 1. | Phosphatidylinositol 3-kinase regulatory subunit alpha; Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation [...] | 0.997 |
| CR201_G0037390 | PIK3R3 | ENSPPYP00000010903 | ENSPPYP00000001627 | PIK3R2 isoform 1. | T0148502 isoform 1. | 0.996 |
| FGF1 | CR201_G0037390 | ENSPPYP00000024593 | ENSPPYP00000010903 | Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with int [...] | PIK3R2 isoform 1. | 0.514 |
| FGF1 | FGF17 | ENSPPYP00000024593 | ENSPPYP00000020628 | Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with int [...] | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.769 |
| FGF1 | FGF23 | ENSPPYP00000024593 | ENSPPYP00000005881 | Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with int [...] | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.785 |
| FGF1 | FGF3 | ENSPPYP00000024593 | ENSPPYP00000003430 | Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with int [...] | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.628 |
| FGF1 | FGF4 | ENSPPYP00000024593 | ENSPPYP00000003431 | Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with int [...] | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.645 |
| FGF1 | FGFR1 | ENSPPYP00000024593 | ENSPPYP00000020767 | Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with int [...] | Fibroblast growth factor receptor. | 0.998 |
| FGF1 | FLRT1 | ENSPPYP00000024593 | ENSPPYP00000003604 | Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with int [...] | Fibronectin leucine rich transmembrane protein 1. | 0.577 |
| FGF1 | PIK3R1 | ENSPPYP00000024593 | ENSPPYP00000017341 | Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with int [...] | Phosphatidylinositol 3-kinase regulatory subunit alpha; Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation [...] | 0.541 |
| FGF1 | PIK3R3 | ENSPPYP00000024593 | ENSPPYP00000001627 | Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with int [...] | T0148502 isoform 1. | 0.507 |
| FGF17 | CR201_G0037390 | ENSPPYP00000020628 | ENSPPYP00000010903 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | PIK3R2 isoform 1. | 0.533 |
| FGF17 | FGF1 | ENSPPYP00000020628 | ENSPPYP00000024593 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with int [...] | 0.769 |
