NAA40 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
H2AC20	NAA40	ENSPPYP00000001070	ENSPPYP00000003607	Histone H2A; Belongs to the histone H2A family.	NAA40 isoform 4.	0.653
KIF5B	NAA40	ENSPPYP00000002553	ENSPPYP00000003607	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	NAA40 isoform 4.	0.636
NAA20	NAA30	ENSPPYP00000012011	ENSPPYP00000006647	N(alpha)-acetyltransferase 20, NatB catalytic subunit.	N(alpha)-acetyltransferase 30, NatC catalytic subunit.	0.867
NAA20	NAA40	ENSPPYP00000012011	ENSPPYP00000003607	N(alpha)-acetyltransferase 20, NatB catalytic subunit.	NAA40 isoform 4.	0.750
NAA20	NAA50	ENSPPYP00000012011	ENSPPYP00000015136	N(alpha)-acetyltransferase 20, NatB catalytic subunit.	N-alpha-acetyltransferase 50; N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine. Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides, except for those with a proline in second position. Also displays N-epsilon-acetyltransferase activity by mediating acetylation of the side chain of specific lysines on proteins. Autoacetylates in vivo. The relevance of N-epsilon-acetyltransferase activity is however unclear: able to acetylate H4 in vitro, but this result has not been confirmed in vivo. [...]	0.871
NAA20	NAT10	ENSPPYP00000012011	ENSPPYP00000003867	N(alpha)-acetyltransferase 20, NatB catalytic subunit.	RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.	0.599
NAA30	NAA20	ENSPPYP00000006647	ENSPPYP00000012011	N(alpha)-acetyltransferase 30, NatC catalytic subunit.	N(alpha)-acetyltransferase 20, NatB catalytic subunit.	0.867
NAA30	NAA40	ENSPPYP00000006647	ENSPPYP00000003607	N(alpha)-acetyltransferase 30, NatC catalytic subunit.	NAA40 isoform 4.	0.760
NAA30	NAA50	ENSPPYP00000006647	ENSPPYP00000015136	N(alpha)-acetyltransferase 30, NatC catalytic subunit.	N-alpha-acetyltransferase 50; N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine. Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides, except for those with a proline in second position. Also displays N-epsilon-acetyltransferase activity by mediating acetylation of the side chain of specific lysines on proteins. Autoacetylates in vivo. The relevance of N-epsilon-acetyltransferase activity is however unclear: able to acetylate H4 in vitro, but this result has not been confirmed in vivo. [...]	0.774
NAA30	NAT10	ENSPPYP00000006647	ENSPPYP00000003867	N(alpha)-acetyltransferase 30, NatC catalytic subunit.	RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.	0.568
NAA40	H2AC20	ENSPPYP00000003607	ENSPPYP00000001070	NAA40 isoform 4.	Histone H2A; Belongs to the histone H2A family.	0.653
NAA40	KIF5B	ENSPPYP00000003607	ENSPPYP00000002553	NAA40 isoform 4.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.636
NAA40	NAA20	ENSPPYP00000003607	ENSPPYP00000012011	NAA40 isoform 4.	N(alpha)-acetyltransferase 20, NatB catalytic subunit.	0.750
NAA40	NAA30	ENSPPYP00000003607	ENSPPYP00000006647	NAA40 isoform 4.	N(alpha)-acetyltransferase 30, NatC catalytic subunit.	0.760
NAA40	NAA50	ENSPPYP00000003607	ENSPPYP00000015136	NAA40 isoform 4.	N-alpha-acetyltransferase 50; N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine. Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides, except for those with a proline in second position. Also displays N-epsilon-acetyltransferase activity by mediating acetylation of the side chain of specific lysines on proteins. Autoacetylates in vivo. The relevance of N-epsilon-acetyltransferase activity is however unclear: able to acetylate H4 in vitro, but this result has not been confirmed in vivo. [...]	0.726
NAA40	NAT10	ENSPPYP00000003607	ENSPPYP00000003867	NAA40 isoform 4.	RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.	0.634
NAA40	SSRP1	ENSPPYP00000003607	ENSPPYP00000024077	NAA40 isoform 4.	FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...]	0.656
NAA40	WDR11	ENSPPYP00000003607	ENSPPYP00000024337	NAA40 isoform 4.	WDR11 isoform 1.	0.915
NAA40	XPC	ENSPPYP00000003607	ENSPPYP00000014988	NAA40 isoform 4.	XPC complex subunit, DNA damage recognition and repair factor.	0.736
NAA40	XPOT	ENSPPYP00000003607	ENSPPYP00000005384	NAA40 isoform 4.	Exportin-T; Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of nucl [...]	0.840