GNG3 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GABBR2	GNAI1	ENSPPYP00000021779	ENSPPYP00000020020	GABBR2 isoform 2.	Guanine nucleotide-binding protein G(i) subunit alpha-1.	0.420
GABBR2	GNAI3	ENSPPYP00000021779	ENSPPYP00000001241	GABBR2 isoform 2.	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]	0.937
GABBR2	GNAO1	ENSPPYP00000021779	ENSPPYP00000008317	GABBR2 isoform 2.	GNAO1 isoform 1.	0.937
GABBR2	GNB1	ENSPPYP00000021779	ENSPPYP00000002307	GABBR2 isoform 2.	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.960
GABBR2	GNB2	ENSPPYP00000021779	ENSPPYP00000019528	GABBR2 isoform 2.	GNB2 isoform 1.	0.952
GABBR2	GNB3	ENSPPYP00000021779	ENSPPYP00000004790	GABBR2 isoform 2.	G protein subunit beta 3.	0.955
GABBR2	GNB5	ENSPPYP00000021779	ENSPPYP00000007348	GABBR2 isoform 2.	Guanine nucleotide-binding protein subunit beta-5; Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, incl [...]	0.965
GABBR2	GNG3	ENSPPYP00000021779	ENSPPYP00000003639	GABBR2 isoform 2.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.954
GABBR2	OPRM1	ENSPPYP00000021779	ENSPPYP00000024191	GABBR2 isoform 2.	Opioid receptor mu 1; Belongs to the G-protein coupled receptor 1 family.	0.404
GNAI1	GABBR2	ENSPPYP00000020020	ENSPPYP00000021779	Guanine nucleotide-binding protein G(i) subunit alpha-1.	GABBR2 isoform 2.	0.420
GNAI1	GNAI3	ENSPPYP00000020020	ENSPPYP00000001241	Guanine nucleotide-binding protein G(i) subunit alpha-1.	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]	0.995
GNAI1	GNAO1	ENSPPYP00000020020	ENSPPYP00000008317	Guanine nucleotide-binding protein G(i) subunit alpha-1.	GNAO1 isoform 1.	0.824
GNAI1	GNAS	ENSPPYP00000020020	ENSPPYP00000012485	Guanine nucleotide-binding protein G(i) subunit alpha-1.	GNAS isoform 2.	0.504
GNAI1	GNB1	ENSPPYP00000020020	ENSPPYP00000002307	Guanine nucleotide-binding protein G(i) subunit alpha-1.	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.973
GNAI1	GNB2	ENSPPYP00000020020	ENSPPYP00000019528	Guanine nucleotide-binding protein G(i) subunit alpha-1.	GNB2 isoform 1.	0.913
GNAI1	GNB3	ENSPPYP00000020020	ENSPPYP00000004790	Guanine nucleotide-binding protein G(i) subunit alpha-1.	G protein subunit beta 3.	0.734
GNAI1	GNB5	ENSPPYP00000020020	ENSPPYP00000007348	Guanine nucleotide-binding protein G(i) subunit alpha-1.	Guanine nucleotide-binding protein subunit beta-5; Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, incl [...]	0.660
GNAI1	GNG3	ENSPPYP00000020020	ENSPPYP00000003639	Guanine nucleotide-binding protein G(i) subunit alpha-1.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.961
GNAI1	OPRM1	ENSPPYP00000020020	ENSPPYP00000024191	Guanine nucleotide-binding protein G(i) subunit alpha-1.	Opioid receptor mu 1; Belongs to the G-protein coupled receptor 1 family.	0.800
GNAI3	GABBR2	ENSPPYP00000001241	ENSPPYP00000021779	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]	GABBR2 isoform 2.	0.937