| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARHGAP31 | DOCK6 | ENSPPYP00000015118 | ENSPPYP00000010736 | Rho GTPase activating protein 31. | DOCK6 isoform 2; Belongs to the DOCK family. | 0.549 |
| ARHGAP31 | KIF11 | ENSPPYP00000015118 | ENSPPYP00000002878 | Rho GTPase activating protein 31. | Kinesin family member 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.725 |
| ARHGAP31 | RCBTB1 | ENSPPYP00000015118 | ENSPPYP00000006118 | Rho GTPase activating protein 31. | RCC1 and BTB domain containing protein 1. | 0.788 |
| ARHGAP31 | TSPAN12 | ENSPPYP00000015118 | ENSPPYP00000020123 | Rho GTPase activating protein 31. | Tetraspanin-12; Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt- dependent activation of FZD4, suggesting the existence of a Wnt- independent signaling that also [...] | 0.749 |
| ARHGAP31 | ZNF408 | ENSPPYP00000015118 | ENSPPYP00000003809 | Rho GTPase activating protein 31. | ZNF408 isoform 1. | 0.764 |
| CCNJ | GAPDHS | ENSPPYP00000002919 | ENSPPYP00000011047 | CCNJ isoform 1; Belongs to the cyclin family. | Glyceraldehyde-3-phosphate dehydrogenase. | 0.658 |
| CCNJ | ZNF408 | ENSPPYP00000002919 | ENSPPYP00000003809 | CCNJ isoform 1; Belongs to the cyclin family. | ZNF408 isoform 1. | 0.743 |
| DOCK6 | ARHGAP31 | ENSPPYP00000010736 | ENSPPYP00000015118 | DOCK6 isoform 2; Belongs to the DOCK family. | Rho GTPase activating protein 31. | 0.549 |
| DOCK6 | KIF11 | ENSPPYP00000010736 | ENSPPYP00000002878 | DOCK6 isoform 2; Belongs to the DOCK family. | Kinesin family member 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.782 |
| DOCK6 | RCBTB1 | ENSPPYP00000010736 | ENSPPYP00000006118 | DOCK6 isoform 2; Belongs to the DOCK family. | RCC1 and BTB domain containing protein 1. | 0.801 |
| DOCK6 | TSPAN12 | ENSPPYP00000010736 | ENSPPYP00000020123 | DOCK6 isoform 2; Belongs to the DOCK family. | Tetraspanin-12; Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt- dependent activation of FZD4, suggesting the existence of a Wnt- independent signaling that also [...] | 0.788 |
| DOCK6 | ZNF408 | ENSPPYP00000010736 | ENSPPYP00000003809 | DOCK6 isoform 2; Belongs to the DOCK family. | ZNF408 isoform 1. | 0.791 |
| FZD4 | KIF11 | ENSPPYP00000004289 | ENSPPYP00000002878 | FZD4 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. | Kinesin family member 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.541 |
| FZD4 | RCBTB1 | ENSPPYP00000004289 | ENSPPYP00000006118 | FZD4 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. | RCC1 and BTB domain containing protein 1. | 0.660 |
| FZD4 | TSPAN12 | ENSPPYP00000004289 | ENSPPYP00000020123 | FZD4 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. | Tetraspanin-12; Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt- dependent activation of FZD4, suggesting the existence of a Wnt- independent signaling that also [...] | 0.796 |
| FZD4 | ZNF408 | ENSPPYP00000004289 | ENSPPYP00000003809 | FZD4 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. | ZNF408 isoform 1. | 0.680 |
| GAPDHS | CCNJ | ENSPPYP00000011047 | ENSPPYP00000002919 | Glyceraldehyde-3-phosphate dehydrogenase. | CCNJ isoform 1; Belongs to the cyclin family. | 0.658 |
| GAPDHS | ZNF408 | ENSPPYP00000011047 | ENSPPYP00000003809 | Glyceraldehyde-3-phosphate dehydrogenase. | ZNF408 isoform 1. | 0.653 |
| GPATCH3 | ZNF408 | ENSPPYP00000001935 | ENSPPYP00000003809 | G-patch domain containing 3. | ZNF408 isoform 1. | 0.950 |
| KIF11 | ARHGAP31 | ENSPPYP00000002878 | ENSPPYP00000015118 | Kinesin family member 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | Rho GTPase activating protein 31. | 0.725 |
