node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATG101 | ATG13 | ENSPPYP00000005179 | ENSPPYP00000003811 | ATG101 isoform 1. | Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity). | 0.999 |
ATG101 | ATG14 | ENSPPYP00000005179 | ENSPPYP00000006635 | ATG101 isoform 1. | Autophagy related 14. | 0.988 |
ATG101 | C9orf72 | ENSPPYP00000005179 | ENSPPYP00000021460 | ATG101 isoform 1. | C9orf72-SMCR8 complex subunit. | 0.956 |
ATG101 | MLST8 | ENSPPYP00000005179 | ENSPPYP00000007913 | ATG101 isoform 1. | MTOR associated protein, LST8 homolog. | 0.970 |
ATG101 | PIK3C3 | ENSPPYP00000005179 | ENSPPYP00000010247 | ATG101 isoform 1. | Phosphatidylinositol 3-kinase catalytic subunit type 3. | 0.985 |
ATG101 | PIK3R4 | ENSPPYP00000005179 | ENSPPYP00000015770 | ATG101 isoform 1. | Phosphoinositide 3-kinase regulatory subunit 4; Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (By similarity). | 0.984 |
ATG101 | RB1CC1 | ENSPPYP00000005179 | ENSPPYP00000020840 | ATG101 isoform 1. | RB1CC1 isoform 1. | 0.999 |
ATG101 | RPTOR | ENSPPYP00000005179 | ENSPPYP00000024617 | ATG101 isoform 1. | RPTOR isoform 4. | 0.980 |
ATG101 | ULK1 | ENSPPYP00000005179 | ENSPPYP00000005848 | ATG101 isoform 1. | Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. | 0.998 |
ATG101 | ULK2 | ENSPPYP00000005179 | ENSPPYP00000009920 | ATG101 isoform 1. | Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. | 0.997 |
ATG13 | ATG101 | ENSPPYP00000003811 | ENSPPYP00000005179 | Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity). | ATG101 isoform 1. | 0.999 |
ATG13 | ATG14 | ENSPPYP00000003811 | ENSPPYP00000006635 | Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity). | Autophagy related 14. | 0.990 |
ATG13 | C9orf72 | ENSPPYP00000003811 | ENSPPYP00000021460 | Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity). | C9orf72-SMCR8 complex subunit. | 0.977 |
ATG13 | MLST8 | ENSPPYP00000003811 | ENSPPYP00000007913 | Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity). | MTOR associated protein, LST8 homolog. | 0.975 |
ATG13 | PIK3C3 | ENSPPYP00000003811 | ENSPPYP00000010247 | Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity). | Phosphatidylinositol 3-kinase catalytic subunit type 3. | 0.988 |
ATG13 | PIK3R4 | ENSPPYP00000003811 | ENSPPYP00000015770 | Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity). | Phosphoinositide 3-kinase regulatory subunit 4; Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (By similarity). | 0.986 |
ATG13 | RB1CC1 | ENSPPYP00000003811 | ENSPPYP00000020840 | Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity). | RB1CC1 isoform 1. | 0.999 |
ATG13 | RPTOR | ENSPPYP00000003811 | ENSPPYP00000024617 | Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity). | RPTOR isoform 4. | 0.986 |
ATG13 | ULK1 | ENSPPYP00000003811 | ENSPPYP00000005848 | Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity). | Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. | 0.999 |
ATG13 | ULK2 | ENSPPYP00000003811 | ENSPPYP00000009920 | Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity). | Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. | 0.998 |