| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AMBRA1 | ATG14 | ENSPPYP00000003814 | ENSPPYP00000006635 | AMBRA1 isoform 3. | Autophagy related 14. | 0.974 |
| AMBRA1 | BECN1 | ENSPPYP00000003814 | ENSPPYP00000009414 | AMBRA1 isoform 3. | Beclin-1-C 35 kDa; Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3- phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex f [...] | 0.998 |
| AMBRA1 | BECN2 | ENSPPYP00000003814 | ENSPPYP00000000063 | AMBRA1 isoform 3. | BECN2 isoform 1. | 0.988 |
| AMBRA1 | DDA1 | ENSPPYP00000003814 | ENSPPYP00000010881 | AMBRA1 isoform 3. | DET1- and DDB1-associated protein 1; May be involved in ubiquitination and subsequent proteasomal degradation of target proteins. Component of the DDD-E2 complexes which may provide a platform for interaction with CUL4A and WD repeat proteins (By similarity); Belongs to the DDA1 family. | 0.963 |
| AMBRA1 | DDB1 | ENSPPYP00000003814 | ENSPPYP00000003683 | AMBRA1 isoform 3. | DNA damage-binding protein 1; Required for DNA repair. Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiqui [...] | 0.971 |
| AMBRA1 | PIK3C3 | ENSPPYP00000003814 | ENSPPYP00000010247 | AMBRA1 isoform 3. | Phosphatidylinositol 3-kinase catalytic subunit type 3. | 0.977 |
| AMBRA1 | PIK3R4 | ENSPPYP00000003814 | ENSPPYP00000015770 | AMBRA1 isoform 3. | Phosphoinositide 3-kinase regulatory subunit 4; Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (By similarity). | 0.975 |
| AMBRA1 | PINK1 | ENSPPYP00000003814 | ENSPPYP00000002052 | AMBRA1 isoform 3. | PTEN induced kinase 1. | 0.964 |
| AMBRA1 | ULK1 | ENSPPYP00000003814 | ENSPPYP00000005848 | AMBRA1 isoform 3. | Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. | 0.992 |
| AMBRA1 | ULK2 | ENSPPYP00000003814 | ENSPPYP00000009920 | AMBRA1 isoform 3. | Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. | 0.979 |
| ATG14 | AMBRA1 | ENSPPYP00000006635 | ENSPPYP00000003814 | Autophagy related 14. | AMBRA1 isoform 3. | 0.974 |
| ATG14 | BECN1 | ENSPPYP00000006635 | ENSPPYP00000009414 | Autophagy related 14. | Beclin-1-C 35 kDa; Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3- phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex f [...] | 0.999 |
| ATG14 | BECN2 | ENSPPYP00000006635 | ENSPPYP00000000063 | Autophagy related 14. | BECN2 isoform 1. | 0.996 |
| ATG14 | PIK3C3 | ENSPPYP00000006635 | ENSPPYP00000010247 | Autophagy related 14. | Phosphatidylinositol 3-kinase catalytic subunit type 3. | 0.999 |
| ATG14 | PIK3R4 | ENSPPYP00000006635 | ENSPPYP00000015770 | Autophagy related 14. | Phosphoinositide 3-kinase regulatory subunit 4; Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (By similarity). | 0.999 |
| ATG14 | ULK1 | ENSPPYP00000006635 | ENSPPYP00000005848 | Autophagy related 14. | Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. | 0.998 |
| ATG14 | ULK2 | ENSPPYP00000006635 | ENSPPYP00000009920 | Autophagy related 14. | Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. | 0.990 |
| BECN1 | AMBRA1 | ENSPPYP00000009414 | ENSPPYP00000003814 | Beclin-1-C 35 kDa; Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3- phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex f [...] | AMBRA1 isoform 3. | 0.998 |
| BECN1 | ATG14 | ENSPPYP00000009414 | ENSPPYP00000006635 | Beclin-1-C 35 kDa; Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3- phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex f [...] | Autophagy related 14. | 0.999 |
| BECN1 | BECN2 | ENSPPYP00000009414 | ENSPPYP00000000063 | Beclin-1-C 35 kDa; Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3- phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex f [...] | BECN2 isoform 1. | 0.905 |
