AMBRA1 protein (Pongo abelii) - STRING interaction network

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Predicted Interactions

gene neighborhood

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gene co-occurrence

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textmining

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protein homology

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Score

AMBRA1

AMBRA1 isoform 3. (1241 aa)

Predicted Functional Partners:

PIK3C3

0.998

BECN1

0.996

PIK3R4

0.994

ATG14

0.992

TRAF6

0.985

ULK2

0.976

BECN2

0.974

NRBF2

0.935

DDB1

0.935

CUL4B

0.932

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMBRA1	ATG14	ENSPPYP00000003814	ENSPPYP00000006635	AMBRA1 isoform 3.	Autophagy related 14.	0.992
AMBRA1	BECN1	ENSPPYP00000003814	ENSPPYP00000009414	AMBRA1 isoform 3.	Beclin-1-C 35 kDa; Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3- phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex f [...]	0.996
AMBRA1	BECN2	ENSPPYP00000003814	ENSPPYP00000000063	AMBRA1 isoform 3.	BECN2 isoform 1.	0.974
AMBRA1	CUL4B	ENSPPYP00000003814	ENSPPYP00000023154	AMBRA1 isoform 3.	CUL4B isoform 4; Belongs to the cullin family.	0.932
AMBRA1	DDB1	ENSPPYP00000003814	ENSPPYP00000003683	AMBRA1 isoform 3.	DNA damage-binding protein 1; Required for DNA repair. Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiqui [...]	0.935
AMBRA1	NRBF2	ENSPPYP00000003814	ENSPPYP00000002795	AMBRA1 isoform 3.	Nuclear receptor-binding factor 2; May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro) (By similarity); Belongs to the NRBF family.	0.935
AMBRA1	PIK3C3	ENSPPYP00000003814	ENSPPYP00000010247	AMBRA1 isoform 3.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.998
AMBRA1	PIK3R4	ENSPPYP00000003814	ENSPPYP00000015770	AMBRA1 isoform 3.	Phosphoinositide 3-kinase regulatory subunit 4; Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (By similarity).	0.994
AMBRA1	TRAF6	ENSPPYP00000003814	ENSPPYP00000003845	AMBRA1 isoform 3.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.985
AMBRA1	ULK2	ENSPPYP00000003814	ENSPPYP00000009920	AMBRA1 isoform 3.	Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.	0.976
ATG14	AMBRA1	ENSPPYP00000006635	ENSPPYP00000003814	Autophagy related 14.	AMBRA1 isoform 3.	0.992
ATG14	BECN1	ENSPPYP00000006635	ENSPPYP00000009414	Autophagy related 14.	Beclin-1-C 35 kDa; Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3- phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex f [...]	0.999
ATG14	BECN2	ENSPPYP00000006635	ENSPPYP00000000063	Autophagy related 14.	BECN2 isoform 1.	0.996
ATG14	NRBF2	ENSPPYP00000006635	ENSPPYP00000002795	Autophagy related 14.	Nuclear receptor-binding factor 2; May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro) (By similarity); Belongs to the NRBF family.	0.991
ATG14	PIK3C3	ENSPPYP00000006635	ENSPPYP00000010247	Autophagy related 14.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.999
ATG14	PIK3R4	ENSPPYP00000006635	ENSPPYP00000015770	Autophagy related 14.	Phosphoinositide 3-kinase regulatory subunit 4; Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (By similarity).	0.999
ATG14	ULK2	ENSPPYP00000006635	ENSPPYP00000009920	Autophagy related 14.	Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.	0.988
BECN1	AMBRA1	ENSPPYP00000009414	ENSPPYP00000003814	Beclin-1-C 35 kDa; Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3- phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex f [...]	AMBRA1 isoform 3.	0.996
BECN1	ATG14	ENSPPYP00000009414	ENSPPYP00000006635	Beclin-1-C 35 kDa; Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3- phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex f [...]	Autophagy related 14.	0.999
BECN1	BECN2	ENSPPYP00000009414	ENSPPYP00000000063	Beclin-1-C 35 kDa; Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3- phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex f [...]	BECN2 isoform 1.	0.570