| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CHUK | IRAK1 | ENSPPYP00000002975 | ENSPPYP00000023353 | CHUK isoform 1. | Interleukin 1 receptor associated kinase 1. | 0.980 |
| CHUK | IRAK2 | ENSPPYP00000002975 | ENSPPYP00000015274 | CHUK isoform 1. | Interleukin-1 receptor-associated kinase-like 2; Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. | 0.627 |
| CHUK | IRAK4 | ENSPPYP00000002975 | ENSPPYP00000005053 | CHUK isoform 1. | IRAK4 isoform 6. | 0.932 |
| CHUK | MAP3K7 | ENSPPYP00000002975 | ENSPPYP00000018861 | CHUK isoform 1. | Mitogen-activated protein kinase kinase kinase 7; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as a [...] | 0.997 |
| CHUK | MYD88 | ENSPPYP00000002975 | ENSPPYP00000015673 | CHUK isoform 1. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. | 0.565 |
| CHUK | NGFR | ENSPPYP00000002975 | ENSPPYP00000010010 | CHUK isoform 1. | NGFR isoform 1. | 0.530 |
| CHUK | SQSTM1 | ENSPPYP00000002975 | ENSPPYP00000018045 | CHUK isoform 1. | Sequestosome-1; Autophagy receptor required for selective macroautophagy (aggrephagy). Functions as a bridge between polyubiquitinated cargo and autophagosomes. Interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin- containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation (By similarity). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and [...] | 0.702 |
| CHUK | SYNGR1 | ENSPPYP00000002975 | ENSPPYP00000013210 | CHUK isoform 1. | Synaptogyrin-1; May play a role in regulated exocytosis. Modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in synaptic-like microvesicle formation and/or maturation (By similarity). Involved in the regulation of short- term and long-term synaptic plasticity (By similarity). Belongs to the synaptogyrin family. | 0.976 |
| CHUK | TAB3 | ENSPPYP00000002975 | ENSPPYP00000022623 | CHUK isoform 1. | TAB3 isoform 2. | 0.980 |
| CHUK | TRAF6 | ENSPPYP00000002975 | ENSPPYP00000003845 | CHUK isoform 1. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.998 |
| IRAK1 | CHUK | ENSPPYP00000023353 | ENSPPYP00000002975 | Interleukin 1 receptor associated kinase 1. | CHUK isoform 1. | 0.980 |
| IRAK1 | IRAK2 | ENSPPYP00000023353 | ENSPPYP00000015274 | Interleukin 1 receptor associated kinase 1. | Interleukin-1 receptor-associated kinase-like 2; Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. | 0.991 |
| IRAK1 | IRAK4 | ENSPPYP00000023353 | ENSPPYP00000005053 | Interleukin 1 receptor associated kinase 1. | IRAK4 isoform 6. | 0.999 |
| IRAK1 | MAP3K7 | ENSPPYP00000023353 | ENSPPYP00000018861 | Interleukin 1 receptor associated kinase 1. | Mitogen-activated protein kinase kinase kinase 7; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as a [...] | 0.991 |
| IRAK1 | MYD88 | ENSPPYP00000023353 | ENSPPYP00000015673 | Interleukin 1 receptor associated kinase 1. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. | 0.999 |
| IRAK1 | NGFR | ENSPPYP00000023353 | ENSPPYP00000010010 | Interleukin 1 receptor associated kinase 1. | NGFR isoform 1. | 0.955 |
| IRAK1 | SQSTM1 | ENSPPYP00000023353 | ENSPPYP00000018045 | Interleukin 1 receptor associated kinase 1. | Sequestosome-1; Autophagy receptor required for selective macroautophagy (aggrephagy). Functions as a bridge between polyubiquitinated cargo and autophagosomes. Interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin- containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation (By similarity). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and [...] | 0.974 |
| IRAK1 | SYNGR1 | ENSPPYP00000023353 | ENSPPYP00000013210 | Interleukin 1 receptor associated kinase 1. | Synaptogyrin-1; May play a role in regulated exocytosis. Modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in synaptic-like microvesicle formation and/or maturation (By similarity). Involved in the regulation of short- term and long-term synaptic plasticity (By similarity). Belongs to the synaptogyrin family. | 0.969 |
| IRAK1 | TAB3 | ENSPPYP00000023353 | ENSPPYP00000022623 | Interleukin 1 receptor associated kinase 1. | TAB3 isoform 2. | 0.977 |
| IRAK1 | TRAF6 | ENSPPYP00000023353 | ENSPPYP00000003845 | Interleukin 1 receptor associated kinase 1. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.999 |
