node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
INPP5E | PI4K2A | ENSPPYP00000022174 | ENSPPYP00000002946 | INPP5E isoform 2. | Phosphatidylinositol 4-kinase type 2 alpha. | 0.908 |
INPP5E | PIK3C2A | ENSPPYP00000022174 | ENSPPYP00000003968 | INPP5E isoform 2. | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha; Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion dow [...] | 0.931 |
INPP5E | PIK3C2B | ENSPPYP00000022174 | ENSPPYP00000000347 | INPP5E isoform 2. | Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family. | 0.931 |
INPP5E | PIK3R1 | ENSPPYP00000022174 | ENSPPYP00000017341 | INPP5E isoform 2. | Phosphatidylinositol 3-kinase regulatory subunit alpha; Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation [...] | 0.923 |
INPP5E | PIK3R3 | ENSPPYP00000022174 | ENSPPYP00000001627 | INPP5E isoform 2. | T0148502 isoform 1. | 0.923 |
INPP5E | PTEN | ENSPPYP00000022174 | ENSPPYP00000002838 | INPP5E isoform 2. | Pongo abelii phosphatase and tensin homolog (PTEN), mRNA; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. | 0.916 |
INPPL1 | PIK3C2A | ENSPPYP00000004172 | ENSPPYP00000003968 | INPPL1 isoform 2. | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha; Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion dow [...] | 0.940 |
INPPL1 | PIK3C2B | ENSPPYP00000004172 | ENSPPYP00000000347 | INPPL1 isoform 2. | Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family. | 0.954 |
INPPL1 | PIK3R1 | ENSPPYP00000004172 | ENSPPYP00000017341 | INPPL1 isoform 2. | Phosphatidylinositol 3-kinase regulatory subunit alpha; Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation [...] | 0.963 |
INPPL1 | PIK3R3 | ENSPPYP00000004172 | ENSPPYP00000001627 | INPPL1 isoform 2. | T0148502 isoform 1. | 0.947 |
INPPL1 | PTEN | ENSPPYP00000004172 | ENSPPYP00000002838 | INPPL1 isoform 2. | Pongo abelii phosphatase and tensin homolog (PTEN), mRNA; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. | 0.946 |
PI4K2A | INPP5E | ENSPPYP00000002946 | ENSPPYP00000022174 | Phosphatidylinositol 4-kinase type 2 alpha. | INPP5E isoform 2. | 0.908 |
PI4K2A | PIK3C2A | ENSPPYP00000002946 | ENSPPYP00000003968 | Phosphatidylinositol 4-kinase type 2 alpha. | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha; Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion dow [...] | 0.923 |
PI4K2A | PIK3C2B | ENSPPYP00000002946 | ENSPPYP00000000347 | Phosphatidylinositol 4-kinase type 2 alpha. | Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family. | 0.907 |
PI4K2A | PIK3R1 | ENSPPYP00000002946 | ENSPPYP00000017341 | Phosphatidylinositol 4-kinase type 2 alpha. | Phosphatidylinositol 3-kinase regulatory subunit alpha; Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation [...] | 0.913 |
PI4K2A | PIK3R3 | ENSPPYP00000002946 | ENSPPYP00000001627 | Phosphatidylinositol 4-kinase type 2 alpha. | T0148502 isoform 1. | 0.918 |
PI4K2A | PTEN | ENSPPYP00000002946 | ENSPPYP00000002838 | Phosphatidylinositol 4-kinase type 2 alpha. | Pongo abelii phosphatase and tensin homolog (PTEN), mRNA; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. | 0.902 |
PIK3C2A | INPP5E | ENSPPYP00000003968 | ENSPPYP00000022174 | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha; Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion dow [...] | INPP5E isoform 2. | 0.931 |
PIK3C2A | INPPL1 | ENSPPYP00000003968 | ENSPPYP00000004172 | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha; Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion dow [...] | INPPL1 isoform 2. | 0.940 |
PIK3C2A | PI4K2A | ENSPPYP00000003968 | ENSPPYP00000002946 | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha; Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion dow [...] | Phosphatidylinositol 4-kinase type 2 alpha. | 0.923 |