| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BTBD10 | CUL3 | ENSPPYP00000003985 | ENSPPYP00000014786 | BTB/POZ domain-containing protein 10; Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated. Plays a role in preventing motor neuronal death and in accelerating the growth of pancreatic beta cells. | CUL3 isoform 1; Belongs to the cullin family. | 0.466 |
| BTBD10 | KCTD10 | ENSPPYP00000003985 | ENSPPYP00000005629 | BTB/POZ domain-containing protein 10; Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated. Plays a role in preventing motor neuronal death and in accelerating the growth of pancreatic beta cells. | Potassium channel tetramerization domain containing 10. | 0.403 |
| BTBD10 | KCTD19 | ENSPPYP00000003985 | ENSPPYP00000008420 | BTB/POZ domain-containing protein 10; Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated. Plays a role in preventing motor neuronal death and in accelerating the growth of pancreatic beta cells. | Potassium channel tetramerization domain containing 19. | 0.457 |
| BTBD10 | TNFAIP1 | ENSPPYP00000003985 | ENSPPYP00000009095 | BTB/POZ domain-containing protein 10; Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated. Plays a role in preventing motor neuronal death and in accelerating the growth of pancreatic beta cells. | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA- dependent DNA polymerase delta activity (By similarity). | 0.423 |
| CUL3 | BTBD10 | ENSPPYP00000014786 | ENSPPYP00000003985 | CUL3 isoform 1; Belongs to the cullin family. | BTB/POZ domain-containing protein 10; Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated. Plays a role in preventing motor neuronal death and in accelerating the growth of pancreatic beta cells. | 0.466 |
| CUL3 | KCTD10 | ENSPPYP00000014786 | ENSPPYP00000005629 | CUL3 isoform 1; Belongs to the cullin family. | Potassium channel tetramerization domain containing 10. | 0.956 |
| CUL3 | KCTD19 | ENSPPYP00000014786 | ENSPPYP00000008420 | CUL3 isoform 1; Belongs to the cullin family. | Potassium channel tetramerization domain containing 19. | 0.552 |
| CUL3 | TNFAIP1 | ENSPPYP00000014786 | ENSPPYP00000009095 | CUL3 isoform 1; Belongs to the cullin family. | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA- dependent DNA polymerase delta activity (By similarity). | 0.880 |
| KCTD10 | BTBD10 | ENSPPYP00000005629 | ENSPPYP00000003985 | Potassium channel tetramerization domain containing 10. | BTB/POZ domain-containing protein 10; Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated. Plays a role in preventing motor neuronal death and in accelerating the growth of pancreatic beta cells. | 0.403 |
| KCTD10 | CUL3 | ENSPPYP00000005629 | ENSPPYP00000014786 | Potassium channel tetramerization domain containing 10. | CUL3 isoform 1; Belongs to the cullin family. | 0.956 |
| KCTD10 | TNFAIP1 | ENSPPYP00000005629 | ENSPPYP00000009095 | Potassium channel tetramerization domain containing 10. | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA- dependent DNA polymerase delta activity (By similarity). | 0.885 |
| KCTD19 | BTBD10 | ENSPPYP00000008420 | ENSPPYP00000003985 | Potassium channel tetramerization domain containing 19. | BTB/POZ domain-containing protein 10; Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated. Plays a role in preventing motor neuronal death and in accelerating the growth of pancreatic beta cells. | 0.457 |
| KCTD19 | CUL3 | ENSPPYP00000008420 | ENSPPYP00000014786 | Potassium channel tetramerization domain containing 19. | CUL3 isoform 1; Belongs to the cullin family. | 0.552 |
| TNFAIP1 | BTBD10 | ENSPPYP00000009095 | ENSPPYP00000003985 | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA- dependent DNA polymerase delta activity (By similarity). | BTB/POZ domain-containing protein 10; Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated. Plays a role in preventing motor neuronal death and in accelerating the growth of pancreatic beta cells. | 0.423 |
| TNFAIP1 | CUL3 | ENSPPYP00000009095 | ENSPPYP00000014786 | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA- dependent DNA polymerase delta activity (By similarity). | CUL3 isoform 1; Belongs to the cullin family. | 0.880 |
| TNFAIP1 | KCTD10 | ENSPPYP00000009095 | ENSPPYP00000005629 | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA- dependent DNA polymerase delta activity (By similarity). | Potassium channel tetramerization domain containing 10. | 0.885 |