| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADIPOQ | ADRB3 | ENSPPYP00000016092 | ENSPPYP00000020755 | Adiponectin, C1Q and collagen domain containing. | ADRB3 isoform 1. | 0.584 |
| ADIPOQ | GHRL | ENSPPYP00000016092 | ENSPPYP00000015270 | Adiponectin, C1Q and collagen domain containing. | Ghrelin and obestatin prepropeptide. | 0.670 |
| ADIPOQ | LEP | ENSPPYP00000016092 | ENSPPYP00000020162 | Adiponectin, C1Q and collagen domain containing. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.936 |
| ADIPOQ | PPARA | ENSPPYP00000016092 | ENSPPYP00000013328 | Adiponectin, C1Q and collagen domain containing. | Peroxisome proliferator activated receptor alpha. | 0.711 |
| ADIPOQ | PPARG | ENSPPYP00000016092 | ENSPPYP00000015259 | Adiponectin, C1Q and collagen domain containing. | Peroxisome proliferator-activated receptor gamma. | 0.774 |
| ADIPOQ | PPARGC1A | ENSPPYP00000016092 | ENSPPYP00000016357 | Adiponectin, C1Q and collagen domain containing. | PPARG coactivator 1 alpha. | 0.757 |
| ADIPOQ | SREBF1 | ENSPPYP00000016092 | ENSPPYP00000009038 | Adiponectin, C1Q and collagen domain containing. | SREBF1 isoform 2. | 0.573 |
| ADIPOQ | UCP2 | ENSPPYP00000016092 | ENSPPYP00000004192 | Adiponectin, C1Q and collagen domain containing. | Mitochondrial uncoupling protein 2; UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat (By similarity). | 0.604 |
| ADRB3 | ADIPOQ | ENSPPYP00000020755 | ENSPPYP00000016092 | ADRB3 isoform 1. | Adiponectin, C1Q and collagen domain containing. | 0.584 |
| ADRB3 | LEP | ENSPPYP00000020755 | ENSPPYP00000020162 | ADRB3 isoform 1. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.523 |
| ADRB3 | PPARA | ENSPPYP00000020755 | ENSPPYP00000013328 | ADRB3 isoform 1. | Peroxisome proliferator activated receptor alpha. | 0.565 |
| ADRB3 | PPARG | ENSPPYP00000020755 | ENSPPYP00000015259 | ADRB3 isoform 1. | Peroxisome proliferator-activated receptor gamma. | 0.526 |
| ADRB3 | PPARGC1A | ENSPPYP00000020755 | ENSPPYP00000016357 | ADRB3 isoform 1. | PPARG coactivator 1 alpha. | 0.589 |
| ADRB3 | UCP2 | ENSPPYP00000020755 | ENSPPYP00000004192 | ADRB3 isoform 1. | Mitochondrial uncoupling protein 2; UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat (By similarity). | 0.607 |
| BCKDK | MTR | ENSPPYP00000008255 | ENSPPYP00000000082 | Protein-serine/threonine kinase. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.680 |
| BCKDK | UCP2 | ENSPPYP00000008255 | ENSPPYP00000004192 | Protein-serine/threonine kinase. | Mitochondrial uncoupling protein 2; UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat (By similarity). | 0.606 |
| GHRL | ADIPOQ | ENSPPYP00000015270 | ENSPPYP00000016092 | Ghrelin and obestatin prepropeptide. | Adiponectin, C1Q and collagen domain containing. | 0.670 |
| GHRL | LEP | ENSPPYP00000015270 | ENSPPYP00000020162 | Ghrelin and obestatin prepropeptide. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.941 |
| GHRL | UCP2 | ENSPPYP00000015270 | ENSPPYP00000004192 | Ghrelin and obestatin prepropeptide. | Mitochondrial uncoupling protein 2; UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat (By similarity). | 0.628 |
| LEP | ADIPOQ | ENSPPYP00000020162 | ENSPPYP00000016092 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | Adiponectin, C1Q and collagen domain containing. | 0.936 |