STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LRRC32Transforming growth factor beta activator LRRC32; Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (By similarity). Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta (By similarity). Controls activation of TGF-beta-1 (TGFB1) on the surface of activa [...] (661 aa)    
Predicted Functional Partners:
TGFB1
Transforming growth factor beta; Belongs to the TGF-beta family.
   
 
 0.965
TGFB3
Transforming growth factor beta; Belongs to the TGF-beta family.
    
 
 0.620
TGFB2
Transforming growth factor beta; Belongs to the TGF-beta family.
    
 
 0.596
ADGRL2
ADGRL2 isoform 14; Belongs to the G-protein coupled receptor 2 family.
    
   0.595
ADGRL1
ADGRL1 isoform 1; Belongs to the G-protein coupled receptor 2 family.
    
   0.595
ADGRL3
ADGRL3 isoform 1; Belongs to the G-protein coupled receptor 2 family.
    
   0.595
EMSY
EMSY isoform 1.
    
 
 0.548
FOXP3
FOXP3 isoform 1.
      
 0.450
NRP1
Neuropilin; Belongs to the neuropilin family.
      
 0.412
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.