node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CASP1 | NLRP1 | ENSPPYP00000004375 | ENSPPYP00000008863 | CASP1 isoform 4; Belongs to the peptidase C14A family. | NLR family pyrin domain containing 1. | 0.975 |
CASP1 | PANX1 | ENSPPYP00000004375 | ENSPPYP00000004323 | CASP1 isoform 4; Belongs to the peptidase C14A family. | Pannexin-1; Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis; Belongs to the pannexin family. | 0.640 |
CASP3 | CASP7 | ENSPPYP00000017020 | ENSPPYP00000003106 | CASP3 isoform 1; Belongs to the peptidase C14A family. | CASP7 isoform 4; Belongs to the peptidase C14A family. | 0.963 |
CASP3 | PANX1 | ENSPPYP00000017020 | ENSPPYP00000004323 | CASP3 isoform 1; Belongs to the peptidase C14A family. | Pannexin-1; Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis; Belongs to the pannexin family. | 0.582 |
CASP7 | CASP3 | ENSPPYP00000003106 | ENSPPYP00000017020 | CASP7 isoform 4; Belongs to the peptidase C14A family. | CASP3 isoform 1; Belongs to the peptidase C14A family. | 0.963 |
CASP7 | PANX1 | ENSPPYP00000003106 | ENSPPYP00000004323 | CASP7 isoform 4; Belongs to the peptidase C14A family. | Pannexin-1; Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis; Belongs to the pannexin family. | 0.613 |
CASP7 | PANX2 | ENSPPYP00000003106 | ENSPPYP00000013358 | CASP7 isoform 4; Belongs to the peptidase C14A family. | Pannexin; Structural component of the gap junctions and the hemichannels; Belongs to the pannexin family. | 0.437 |
CR201_G0000874 | P2RX1 | ENSPPYP00000005641 | ENSPPYP00000008811 | P2RX7 isoform 7. | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. | 0.434 |
CR201_G0000874 | PANX1 | ENSPPYP00000005641 | ENSPPYP00000004323 | P2RX7 isoform 7. | Pannexin-1; Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis; Belongs to the pannexin family. | 0.602 |
GJA1 | PANX1 | ENSPPYP00000019004 | ENSPPYP00000004323 | Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. | Pannexin-1; Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis; Belongs to the pannexin family. | 0.609 |
KCNS1 | PANX1 | ENSPPYP00000012337 | ENSPPYP00000004323 | Potassium voltage-gated channel subfamily S member 1; Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.1/KCNS1 sub-subfamily. | Pannexin-1; Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis; Belongs to the pannexin family. | 0.590 |
NLRP1 | CASP1 | ENSPPYP00000008863 | ENSPPYP00000004375 | NLR family pyrin domain containing 1. | CASP1 isoform 4; Belongs to the peptidase C14A family. | 0.975 |
NLRP1 | PANX1 | ENSPPYP00000008863 | ENSPPYP00000004323 | NLR family pyrin domain containing 1. | Pannexin-1; Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis; Belongs to the pannexin family. | 0.633 |
P2RX1 | CR201_G0000874 | ENSPPYP00000008811 | ENSPPYP00000005641 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. | P2RX7 isoform 7. | 0.434 |
P2RX1 | P2RX7 | ENSPPYP00000008811 | ENSPPYP00000005748 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. | 0.458 |
P2RX1 | PANX1 | ENSPPYP00000008811 | ENSPPYP00000004323 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. | Pannexin-1; Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis; Belongs to the pannexin family. | 0.718 |
P2RX7 | P2RX1 | ENSPPYP00000005748 | ENSPPYP00000008811 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. | 0.458 |
P2RX7 | PANX1 | ENSPPYP00000005748 | ENSPPYP00000004323 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. | Pannexin-1; Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis; Belongs to the pannexin family. | 0.602 |
PANX1 | CASP1 | ENSPPYP00000004323 | ENSPPYP00000004375 | Pannexin-1; Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis; Belongs to the pannexin family. | CASP1 isoform 4; Belongs to the peptidase C14A family. | 0.640 |
PANX1 | CASP3 | ENSPPYP00000004323 | ENSPPYP00000017020 | Pannexin-1; Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis; Belongs to the pannexin family. | CASP3 isoform 1; Belongs to the peptidase C14A family. | 0.582 |