node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EGF | EGFR | ENSPPYP00000016752 | ENSPPYP00000019671 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | Receptor protein-tyrosine kinase. | 0.999 |
EGF | HGF | ENSPPYP00000016752 | ENSPPYP00000020015 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. | 0.962 |
EGF | KIT | ENSPPYP00000016752 | ENSPPYP00000016492 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | 0.954 |
EGF | PDGFB | ENSPPYP00000016752 | ENSPPYP00000013206 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. | 0.940 |
EGF | PDGFC | ENSPPYP00000016752 | ENSPPYP00000016930 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. | 0.920 |
EGF | PDGFD | ENSPPYP00000016752 | ENSPPYP00000004370 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | Platelet-derived growth factor D, receptor-binding form; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix (By similarity). | 0.922 |
EGF | PDGFRA | ENSPPYP00000016752 | ENSPPYP00000016493 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | Platelet-derived growth factor receptor alpha. | 0.966 |
EGF | PDGFRB | ENSPPYP00000016752 | ENSPPYP00000017839 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. | 0.967 |
EGF | VEGFC | ENSPPYP00000016752 | ENSPPYP00000017002 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | VEGFC isoform 1; Belongs to the PDGF/VEGF growth factor family. | 0.952 |
EGF | VEGFD | ENSPPYP00000016752 | ENSPPYP00000022533 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | VEGFD isoform 1; Belongs to the PDGF/VEGF growth factor family. | 0.934 |
EGFR | EGF | ENSPPYP00000019671 | ENSPPYP00000016752 | Receptor protein-tyrosine kinase. | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | 0.999 |
EGFR | HGF | ENSPPYP00000019671 | ENSPPYP00000020015 | Receptor protein-tyrosine kinase. | Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. | 0.901 |
EGFR | PDGFB | ENSPPYP00000019671 | ENSPPYP00000013206 | Receptor protein-tyrosine kinase. | Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. | 0.950 |
EGFR | PDGFC | ENSPPYP00000019671 | ENSPPYP00000016930 | Receptor protein-tyrosine kinase. | Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. | 0.943 |
EGFR | PDGFD | ENSPPYP00000019671 | ENSPPYP00000004370 | Receptor protein-tyrosine kinase. | Platelet-derived growth factor D, receptor-binding form; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix (By similarity). | 0.916 |
EGFR | PDGFRA | ENSPPYP00000019671 | ENSPPYP00000016493 | Receptor protein-tyrosine kinase. | Platelet-derived growth factor receptor alpha. | 0.960 |
EGFR | PDGFRB | ENSPPYP00000019671 | ENSPPYP00000017839 | Receptor protein-tyrosine kinase. | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. | 0.985 |
EGFR | VEGFC | ENSPPYP00000019671 | ENSPPYP00000017002 | Receptor protein-tyrosine kinase. | VEGFC isoform 1; Belongs to the PDGF/VEGF growth factor family. | 0.773 |
EGFR | VEGFD | ENSPPYP00000019671 | ENSPPYP00000022533 | Receptor protein-tyrosine kinase. | VEGFD isoform 1; Belongs to the PDGF/VEGF growth factor family. | 0.802 |
HGF | EGF | ENSPPYP00000020015 | ENSPPYP00000016752 | Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | 0.962 |