CASP5 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIM2	CARD8	ENSPPYP00000000773	ENSPPYP00000011395	Absent in melanoma 2.	Caspase recruitment domain-containing protein 8; Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases (By similarity).	0.759
AIM2	CASP4	ENSPPYP00000000773	ENSPPYP00000004373	Absent in melanoma 2.	CASP4 isoform 2; Belongs to the peptidase C14A family.	0.799
AIM2	CASP5	ENSPPYP00000000773	ENSPPYP00000004374	Absent in melanoma 2.	CASP5 isoform 2; Belongs to the peptidase C14A family.	0.874
AIM2	CR201_G0050806	ENSPPYP00000000773	ENSPPYP00000023911	Absent in melanoma 2.	GSDMD isoform 17.	0.486
AIM2	GSDMD	ENSPPYP00000000773	ENSPPYP00000024281	Absent in melanoma 2.	GSDMD isoform 1.	0.753
AIM2	IL1B	ENSPPYP00000000773	ENSPPYP00000013573	Absent in melanoma 2.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.521
AIM2	NAIP	ENSPPYP00000000773	ENSPPYP00000017359	Absent in melanoma 2.	NAIP isoform 3.	0.747
AIM2	NLRC4	ENSPPYP00000000773	ENSPPYP00000013968	Absent in melanoma 2.	NLRC4 isoform 1.	0.849
AIM2	NLRP1	ENSPPYP00000000773	ENSPPYP00000008863	Absent in melanoma 2.	NLR family pyrin domain containing 1.	0.907
AIM2	PYCARD	ENSPPYP00000000773	ENSPPYP00000008260	Absent in melanoma 2.	PYD and CARD domain containing.	0.998
CARD8	AIM2	ENSPPYP00000011395	ENSPPYP00000000773	Caspase recruitment domain-containing protein 8; Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases (By similarity).	Absent in melanoma 2.	0.759
CARD8	CASP4	ENSPPYP00000011395	ENSPPYP00000004373	Caspase recruitment domain-containing protein 8; Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases (By similarity).	CASP4 isoform 2; Belongs to the peptidase C14A family.	0.697
CARD8	CASP5	ENSPPYP00000011395	ENSPPYP00000004374	Caspase recruitment domain-containing protein 8; Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases (By similarity).	CASP5 isoform 2; Belongs to the peptidase C14A family.	0.800
CARD8	CR201_G0050806	ENSPPYP00000011395	ENSPPYP00000023911	Caspase recruitment domain-containing protein 8; Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases (By similarity).	GSDMD isoform 17.	0.444
CARD8	GSDMD	ENSPPYP00000011395	ENSPPYP00000024281	Caspase recruitment domain-containing protein 8; Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases (By similarity).	GSDMD isoform 1.	0.732
CARD8	IL1B	ENSPPYP00000011395	ENSPPYP00000013573	Caspase recruitment domain-containing protein 8; Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases (By similarity).	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.511
CARD8	NAIP	ENSPPYP00000011395	ENSPPYP00000017359	Caspase recruitment domain-containing protein 8; Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases (By similarity).	NAIP isoform 3.	0.718
CARD8	NLRC4	ENSPPYP00000011395	ENSPPYP00000013968	Caspase recruitment domain-containing protein 8; Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases (By similarity).	NLRC4 isoform 1.	0.733
CARD8	NLRP1	ENSPPYP00000011395	ENSPPYP00000008863	Caspase recruitment domain-containing protein 8; Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases (By similarity).	NLR family pyrin domain containing 1.	0.617
CARD8	PYCARD	ENSPPYP00000011395	ENSPPYP00000008260	Caspase recruitment domain-containing protein 8; Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases (By similarity).	PYD and CARD domain containing.	0.684