| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AIM2 | CARD18 | ENSPPYP00000000773 | ENSPPYP00000004378 | Absent in melanoma 2. | CARD18 isoform 1. | 0.707 |
| AIM2 | CASP1 | ENSPPYP00000000773 | ENSPPYP00000004375 | Absent in melanoma 2. | CASP1 isoform 4; Belongs to the peptidase C14A family. | 0.993 |
| AIM2 | GSDMD | ENSPPYP00000000773 | ENSPPYP00000024281 | Absent in melanoma 2. | GSDMD isoform 1. | 0.753 |
| AIM2 | IL18 | ENSPPYP00000000773 | ENSPPYP00000004441 | Absent in melanoma 2. | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. | 0.775 |
| AIM2 | IL1B | ENSPPYP00000000773 | ENSPPYP00000013573 | Absent in melanoma 2. | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | 0.521 |
| AIM2 | MEFV | ENSPPYP00000000773 | ENSPPYP00000007958 | Absent in melanoma 2. | MEFV isoform 4. | 0.809 |
| AIM2 | NLRC4 | ENSPPYP00000000773 | ENSPPYP00000013968 | Absent in melanoma 2. | NLRC4 isoform 1. | 0.849 |
| AIM2 | NLRP1 | ENSPPYP00000000773 | ENSPPYP00000008863 | Absent in melanoma 2. | NLR family pyrin domain containing 1. | 0.907 |
| AIM2 | PYCARD | ENSPPYP00000000773 | ENSPPYP00000008260 | Absent in melanoma 2. | PYD and CARD domain containing. | 0.998 |
| CARD18 | AIM2 | ENSPPYP00000004378 | ENSPPYP00000000773 | CARD18 isoform 1. | Absent in melanoma 2. | 0.707 |
| CARD18 | CASP1 | ENSPPYP00000004378 | ENSPPYP00000004375 | CARD18 isoform 1. | CASP1 isoform 4; Belongs to the peptidase C14A family. | 0.981 |
| CARD18 | GSDMD | ENSPPYP00000004378 | ENSPPYP00000024281 | CARD18 isoform 1. | GSDMD isoform 1. | 0.786 |
| CARD18 | IL18 | ENSPPYP00000004378 | ENSPPYP00000004441 | CARD18 isoform 1. | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. | 0.546 |
| CARD18 | IL1B | ENSPPYP00000004378 | ENSPPYP00000013573 | CARD18 isoform 1. | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | 0.653 |
| CARD18 | MEFV | ENSPPYP00000004378 | ENSPPYP00000007958 | CARD18 isoform 1. | MEFV isoform 4. | 0.458 |
| CARD18 | NLRC4 | ENSPPYP00000004378 | ENSPPYP00000013968 | CARD18 isoform 1. | NLRC4 isoform 1. | 0.652 |
| CARD18 | NLRP1 | ENSPPYP00000004378 | ENSPPYP00000008863 | CARD18 isoform 1. | NLR family pyrin domain containing 1. | 0.705 |
| CARD18 | PYCARD | ENSPPYP00000004378 | ENSPPYP00000008260 | CARD18 isoform 1. | PYD and CARD domain containing. | 0.796 |
| CASP1 | AIM2 | ENSPPYP00000004375 | ENSPPYP00000000773 | CASP1 isoform 4; Belongs to the peptidase C14A family. | Absent in melanoma 2. | 0.993 |
| CASP1 | CARD18 | ENSPPYP00000004375 | ENSPPYP00000004378 | CASP1 isoform 4; Belongs to the peptidase C14A family. | CARD18 isoform 1. | 0.981 |
