CUL5 protein (Pongo abelii) - STRING interaction network

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CUL5

Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...] (732 aa)

Predicted Functional Partners:

RNF7

0.999

RBX1

0.998

ELOB

0.995

ELOC

0.995

NEDD8

0.987

ENSPPYP00000004644

0.983

ENSPPYP00000023677

0.983

CR201_G0015086

0.980

SOCS2

0.977

CISH

0.975

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CISH	CUL5	ENSPPYP00000015482	ENSPPYP00000004398	Cytokine inducible SH2 containing protein.	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	0.975
CISH	ELOB	ENSPPYP00000015482	ENSPPYP00000007934	Cytokine inducible SH2 containing protein.	ELOB isoform 1.	0.863
CISH	ELOC	ENSPPYP00000015482	ENSPPYP00000020952	Cytokine inducible SH2 containing protein.	ELOC isoform 10; Belongs to the SKP1 family.	0.867
CISH	ENSPPYP00000004644	ENSPPYP00000015482	ENSPPYP00000004644	Cytokine inducible SH2 containing protein.	annotation not available	0.863
CISH	ENSPPYP00000023677	ENSPPYP00000015482	ENSPPYP00000023677	Cytokine inducible SH2 containing protein.	annotation not available	0.867
CISH	NEDD8	ENSPPYP00000015482	ENSPPYP00000006472	Cytokine inducible SH2 containing protein.	Ubiquitin-like protein Nedd8.	0.564
CISH	RBX1	ENSPPYP00000015482	ENSPPYP00000013235	Cytokine inducible SH2 containing protein.	RBX1 isoform 1.	0.676
CISH	RNF7	ENSPPYP00000015482	ENSPPYP00000015846	Cytokine inducible SH2 containing protein.	Ring finger protein 7.	0.892
CISH	SOCS2	ENSPPYP00000015482	ENSPPYP00000005514	Cytokine inducible SH2 containing protein.	Suppressor of cytokine signaling 2.	0.432
CR201_G0015086	CUL5	ENSPPYP00000008404	ENSPPYP00000004398	CBFB isoform 2.	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	0.980
CR201_G0015086	ELOB	ENSPPYP00000008404	ENSPPYP00000007934	CBFB isoform 2.	ELOB isoform 1.	0.954
CR201_G0015086	ELOC	ENSPPYP00000008404	ENSPPYP00000020952	CBFB isoform 2.	ELOC isoform 10; Belongs to the SKP1 family.	0.957
CR201_G0015086	ENSPPYP00000004644	ENSPPYP00000008404	ENSPPYP00000004644	CBFB isoform 2.	annotation not available	0.954
CR201_G0015086	ENSPPYP00000023677	ENSPPYP00000008404	ENSPPYP00000023677	CBFB isoform 2.	annotation not available	0.957
CR201_G0015086	NEDD8	ENSPPYP00000008404	ENSPPYP00000006472	CBFB isoform 2.	Ubiquitin-like protein Nedd8.	0.411
CR201_G0015086	RBX1	ENSPPYP00000008404	ENSPPYP00000013235	CBFB isoform 2.	RBX1 isoform 1.	0.424
CR201_G0015086	RNF7	ENSPPYP00000008404	ENSPPYP00000015846	CBFB isoform 2.	Ring finger protein 7.	0.844
CUL5	CISH	ENSPPYP00000004398	ENSPPYP00000015482	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	Cytokine inducible SH2 containing protein.	0.975
CUL5	CR201_G0015086	ENSPPYP00000004398	ENSPPYP00000008404	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	CBFB isoform 2.	0.980
CUL5	ELOB	ENSPPYP00000004398	ENSPPYP00000007934	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	ELOB isoform 1.	0.995

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