| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CRTC2 | CRTC3 | ENSPPYP00000000929 | ENSPPYP00000007693 | CRTC2 isoform 3. | CRTC3 isoform 4. | 0.903 |
| CRTC2 | ENSPPYP00000023003 | ENSPPYP00000000929 | ENSPPYP00000023003 | CRTC2 isoform 3. | annotation not available | 0.740 |
| CRTC2 | SIK2 | ENSPPYP00000000929 | ENSPPYP00000004424 | CRTC2 isoform 3. | Serine/threonine-protein kinase SIK2; Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators (By similarity). | 0.987 |
| CRTC2 | YWHAQ | ENSPPYP00000000929 | ENSPPYP00000014137 | CRTC2 isoform 3. | 14-3-3 protein theta; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity). | 0.795 |
| CRTC3 | CRTC2 | ENSPPYP00000007693 | ENSPPYP00000000929 | CRTC3 isoform 4. | CRTC2 isoform 3. | 0.903 |
| CRTC3 | SIK2 | ENSPPYP00000007693 | ENSPPYP00000004424 | CRTC3 isoform 4. | Serine/threonine-protein kinase SIK2; Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators (By similarity). | 0.769 |
| ENSPPYP00000023003 | CRTC2 | ENSPPYP00000023003 | ENSPPYP00000000929 | annotation not available | CRTC2 isoform 3. | 0.740 |
| ENSPPYP00000023003 | PPP2CB | ENSPPYP00000023003 | ENSPPYP00000020727 | annotation not available | Serine/threonine-protein phosphatase. | 0.460 |
| ENSPPYP00000023003 | SIK2 | ENSPPYP00000023003 | ENSPPYP00000004424 | annotation not available | Serine/threonine-protein kinase SIK2; Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators (By similarity). | 0.595 |
| PPP2CB | ENSPPYP00000023003 | ENSPPYP00000020727 | ENSPPYP00000023003 | Serine/threonine-protein phosphatase. | annotation not available | 0.460 |
| PPP2CB | PPP2R1A | ENSPPYP00000020727 | ENSPPYP00000011577 | Serine/threonine-protein phosphatase. | PPP2R1A isoform 7. | 0.990 |
| PPP2CB | PPP2R2C | ENSPPYP00000020727 | ENSPPYP00000016297 | Serine/threonine-protein phosphatase. | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. | 0.982 |
| PPP2CB | SIK2 | ENSPPYP00000020727 | ENSPPYP00000004424 | Serine/threonine-protein phosphatase. | Serine/threonine-protein kinase SIK2; Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators (By similarity). | 0.607 |
| PPP2CB | VCP | ENSPPYP00000020727 | ENSPPYP00000021408 | Serine/threonine-protein phosphatase. | Transitional endoplasmic reticulum ATPase isoform X1. | 0.572 |
| PPP2CB | YWHAQ | ENSPPYP00000020727 | ENSPPYP00000014137 | Serine/threonine-protein phosphatase. | 14-3-3 protein theta; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity). | 0.460 |
| PPP2R1A | PPP2CB | ENSPPYP00000011577 | ENSPPYP00000020727 | PPP2R1A isoform 7. | Serine/threonine-protein phosphatase. | 0.990 |
| PPP2R1A | PPP2R2C | ENSPPYP00000011577 | ENSPPYP00000016297 | PPP2R1A isoform 7. | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. | 0.940 |
| PPP2R1A | SIK2 | ENSPPYP00000011577 | ENSPPYP00000004424 | PPP2R1A isoform 7. | Serine/threonine-protein kinase SIK2; Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators (By similarity). | 0.646 |
| PPP2R1A | VCP | ENSPPYP00000011577 | ENSPPYP00000021408 | PPP2R1A isoform 7. | Transitional endoplasmic reticulum ATPase isoform X1. | 0.773 |
| PPP2R2C | PPP2CB | ENSPPYP00000016297 | ENSPPYP00000020727 | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. | Serine/threonine-protein phosphatase. | 0.982 |
