Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
co-expression
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gene co-occurrence
gene fusions
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PTS6-pyruvoyl tetrahydrobiopterin synthase; Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin (By similarity). (113 aa)    
Predicted Functional Partners:
GCH1
GTP cyclohydrolase 1.
  
 
 0.991
SPR
Sepiapterin reductase.
  
 
 0.972
CBR1
Carbonyl reductase [NADPH] 1; NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2- alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S- nitrosoglutathione (By similarity) [...]
  
 
 0.921
AKR1B1
Aldo-keto reductase family 1 member B.
    
 0.902
AKR1C8P
Prostaglandin F synthase 1-like isoform X1.
    
 0.901
AKR1B10
Aldo-keto reductase family 1 member B10.
    
 0.901
ALPL
Alkaline phosphatase.
     
  0.900
ALPG
Alkaline phosphatase.
     
  0.900
GCHFR
GTP cyclohydrolase I feedback regulator.
     
 0.877
PRKG2
cGMP-dependent protein kinase.
   
  0.840
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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