DRD2 protein (Pongo abelii) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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proteins of unknown 3D structure

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Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARRB1	ARRB2	ENSPPYP00000004214	ENSPPYP00000008826	ARRB1 isoform 2.	Beta-arrestin-2; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta- arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin- associated sorting proteins) and re [...]	0.994
ARRB1	DRD2	ENSPPYP00000004214	ENSPPYP00000004451	ARRB1 isoform 2.	DRD2 isoform 2; Belongs to the G-protein coupled receptor 1 family.	0.972
ARRB1	DRD3	ENSPPYP00000004214	ENSPPYP00000015127	ARRB1 isoform 2.	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.	0.495
ARRB1	DRD4	ENSPPYP00000004214	ENSPPYP00000003343	ARRB1 isoform 2.	DRD4 isoform 1; Belongs to the G-protein coupled receptor 1 family.	0.516
ARRB1	GNB1	ENSPPYP00000004214	ENSPPYP00000002307	ARRB1 isoform 2.	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.817
ARRB1	GNB2	ENSPPYP00000004214	ENSPPYP00000019528	ARRB1 isoform 2.	GNB2 isoform 1.	0.487
ARRB2	ARRB1	ENSPPYP00000008826	ENSPPYP00000004214	Beta-arrestin-2; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta- arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin- associated sorting proteins) and re [...]	ARRB1 isoform 2.	0.994
ARRB2	DRD2	ENSPPYP00000008826	ENSPPYP00000004451	Beta-arrestin-2; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta- arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin- associated sorting proteins) and re [...]	DRD2 isoform 2; Belongs to the G-protein coupled receptor 1 family.	0.990
ARRB2	DRD3	ENSPPYP00000008826	ENSPPYP00000015127	Beta-arrestin-2; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta- arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin- associated sorting proteins) and re [...]	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.	0.495
ARRB2	DRD4	ENSPPYP00000008826	ENSPPYP00000003343	Beta-arrestin-2; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta- arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin- associated sorting proteins) and re [...]	DRD4 isoform 1; Belongs to the G-protein coupled receptor 1 family.	0.701
ARRB2	GNB1	ENSPPYP00000008826	ENSPPYP00000002307	Beta-arrestin-2; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta- arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin- associated sorting proteins) and re [...]	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.487
ARRB2	GNB2	ENSPPYP00000008826	ENSPPYP00000019528	Beta-arrestin-2; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta- arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin- associated sorting proteins) and re [...]	GNB2 isoform 1.	0.491
DRD2	ARRB1	ENSPPYP00000004451	ENSPPYP00000004214	DRD2 isoform 2; Belongs to the G-protein coupled receptor 1 family.	ARRB1 isoform 2.	0.972
DRD2	ARRB2	ENSPPYP00000004451	ENSPPYP00000008826	DRD2 isoform 2; Belongs to the G-protein coupled receptor 1 family.	Beta-arrestin-2; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta- arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin- associated sorting proteins) and re [...]	0.990
DRD2	DRD3	ENSPPYP00000004451	ENSPPYP00000015127	DRD2 isoform 2; Belongs to the G-protein coupled receptor 1 family.	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.	0.973
DRD2	DRD4	ENSPPYP00000004451	ENSPPYP00000003343	DRD2 isoform 2; Belongs to the G-protein coupled receptor 1 family.	DRD4 isoform 1; Belongs to the G-protein coupled receptor 1 family.	0.971
DRD2	GNAI3	ENSPPYP00000004451	ENSPPYP00000001241	DRD2 isoform 2; Belongs to the G-protein coupled receptor 1 family.	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]	0.973
DRD2	GNAO1	ENSPPYP00000004451	ENSPPYP00000008317	DRD2 isoform 2; Belongs to the G-protein coupled receptor 1 family.	GNAO1 isoform 1.	0.964
DRD2	GNB1	ENSPPYP00000004451	ENSPPYP00000002307	DRD2 isoform 2; Belongs to the G-protein coupled receptor 1 family.	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.981
DRD2	GNB2	ENSPPYP00000004451	ENSPPYP00000019528	DRD2 isoform 2; Belongs to the G-protein coupled receptor 1 family.	GNB2 isoform 1.	0.973