PHLDB1 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARRDC3	C2orf80	ENSPPYP00000017472	ENSPPYP00000014666	Arrestin domain-containing protein 3; Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein- coupled receptors. Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation. May recruit NEDD4 to ADRB2. Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes.	Uncharacterized protein C2orf80 homolog.	0.664
ARRDC3	D2HGDH	ENSPPYP00000017472	ENSPPYP00000014198	Arrestin domain-containing protein 3; Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein- coupled receptors. Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation. May recruit NEDD4 to ADRB2. Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes.	D2HGDH isoform 1.	0.667
ARRDC3	ETFA	ENSPPYP00000017472	ENSPPYP00000007571	Arrestin domain-containing protein 3; Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein- coupled receptors. Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation. May recruit NEDD4 to ADRB2. Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes.	Electron transfer flavoprotein subunit alpha, mitochondrial; Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF- ubiquinone oxidoreductase (ETF dehydrogenase). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism.	0.639
ARRDC3	GMEB2	ENSPPYP00000017472	ENSPPYP00000012559	Arrestin domain-containing protein 3; Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein- coupled receptors. Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation. May recruit NEDD4 to ADRB2. Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes.	Glucocorticoid modulatory element binding protein 2.	0.612
ARRDC3	PHLDB1	ENSPPYP00000017472	ENSPPYP00000004513	Arrestin domain-containing protein 3; Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein- coupled receptors. Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation. May recruit NEDD4 to ADRB2. Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes.	PHLDB1 isoform 1.	0.667
ARRDC3	RHBDF1	ENSPPYP00000017472	ENSPPYP00000007807	Arrestin domain-containing protein 3; Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein- coupled receptors. Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation. May recruit NEDD4 to ADRB2. Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes.	Rhomboid 5 homolog 1.	0.664
ARRDC3	RHBDF2	ENSPPYP00000017472	ENSPPYP00000009727	Arrestin domain-containing protein 3; Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein- coupled receptors. Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation. May recruit NEDD4 to ADRB2. Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes.	RHBDF2 isoform 4.	0.512
C2orf80	ARRDC3	ENSPPYP00000014666	ENSPPYP00000017472	Uncharacterized protein C2orf80 homolog.	Arrestin domain-containing protein 3; Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein- coupled receptors. Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation. May recruit NEDD4 to ADRB2. Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes.	0.664
C2orf80	D2HGDH	ENSPPYP00000014666	ENSPPYP00000014198	Uncharacterized protein C2orf80 homolog.	D2HGDH isoform 1.	0.661
C2orf80	ETFA	ENSPPYP00000014666	ENSPPYP00000007571	Uncharacterized protein C2orf80 homolog.	Electron transfer flavoprotein subunit alpha, mitochondrial; Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF- ubiquinone oxidoreductase (ETF dehydrogenase). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism.	0.655
C2orf80	GMEB2	ENSPPYP00000014666	ENSPPYP00000012559	Uncharacterized protein C2orf80 homolog.	Glucocorticoid modulatory element binding protein 2.	0.627
C2orf80	PHLDB1	ENSPPYP00000014666	ENSPPYP00000004513	Uncharacterized protein C2orf80 homolog.	PHLDB1 isoform 1.	0.674
C2orf80	RHBDF1	ENSPPYP00000014666	ENSPPYP00000007807	Uncharacterized protein C2orf80 homolog.	Rhomboid 5 homolog 1.	0.674
C2orf80	RHBDF2	ENSPPYP00000014666	ENSPPYP00000009727	Uncharacterized protein C2orf80 homolog.	RHBDF2 isoform 4.	0.513
CHAMP1	PHLDB1	ENSPPYP00000006311	ENSPPYP00000004513	Chromosome alignment maintaining phosphoprotein 1.	PHLDB1 isoform 1.	0.556
CHAMP1	RTTN	ENSPPYP00000006311	ENSPPYP00000010361	Chromosome alignment maintaining phosphoprotein 1.	RTTN isoform 2.	0.461
CHAMP1	SASS6	ENSPPYP00000006311	ENSPPYP00000001299	Chromosome alignment maintaining phosphoprotein 1.	SAS-6 centriolar assembly protein.	0.492
D2HGDH	ARRDC3	ENSPPYP00000014198	ENSPPYP00000017472	D2HGDH isoform 1.	Arrestin domain-containing protein 3; Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein- coupled receptors. Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation. May recruit NEDD4 to ADRB2. Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes.	0.667
D2HGDH	C2orf80	ENSPPYP00000014198	ENSPPYP00000014666	D2HGDH isoform 1.	Uncharacterized protein C2orf80 homolog.	0.661
D2HGDH	ETFA	ENSPPYP00000014198	ENSPPYP00000007571	D2HGDH isoform 1.	Electron transfer flavoprotein subunit alpha, mitochondrial; Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF- ubiquinone oxidoreductase (ETF dehydrogenase). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism.	0.640