Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of proteins in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CH25H | CYP51A1 | ENSPPYP00000002851 | ENSPPYP00000019976 | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | 0.941 |
| CH25H | DHCR24 | ENSPPYP00000002851 | ENSPPYP00000001525 | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. | DHCR24 isoform 1. | 0.908 |
| CH25H | DHCR7 | ENSPPYP00000002851 | ENSPPYP00000003422 | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. | DHCR7 isoform 1. | 0.934 |
| CH25H | ERG28 | ENSPPYP00000002851 | ENSPPYP00000006832 | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. | Ergosterol biosynthetic protein 28 homolog. | 0.777 |
| CH25H | FDFT1 | ENSPPYP00000002851 | ENSPPYP00000020559 | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. | Squalene synthase; Critical branch point enzyme of isoprenoid biosynthesis that is thought to regulate the flux of isoprene intermediates through the sterol pathway; Belongs to the phytoene/squalene synthase family. | 0.819 |
| CH25H | HSD17B7 | ENSPPYP00000002851 | ENSPPYP00000000676 | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. | HSD17B7 isoform 2. | 0.851 |
| CH25H | LSS | ENSPPYP00000002851 | ENSPPYP00000012870 | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. | Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family. | 0.811 |
| CH25H | SC5D | ENSPPYP00000002851 | ENSPPYP00000004558 | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. | Sterol-C5-desaturase; Belongs to the sterol desaturase family. | 0.934 |
| CYP51A1 | CH25H | ENSPPYP00000019976 | ENSPPYP00000002851 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. | 0.941 |
| CYP51A1 | DHCR24 | ENSPPYP00000019976 | ENSPPYP00000001525 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | DHCR24 isoform 1. | 0.986 |
| CYP51A1 | DHCR7 | ENSPPYP00000019976 | ENSPPYP00000003422 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | DHCR7 isoform 1. | 0.915 |
| CYP51A1 | ERG28 | ENSPPYP00000019976 | ENSPPYP00000006832 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | Ergosterol biosynthetic protein 28 homolog. | 0.959 |
| CYP51A1 | FAXDC2 | ENSPPYP00000019976 | ENSPPYP00000017878 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | Fatty acid hydroxylase domain containing 2; Belongs to the sterol desaturase family. | 0.939 |
| CYP51A1 | FDFT1 | ENSPPYP00000019976 | ENSPPYP00000020559 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | Squalene synthase; Critical branch point enzyme of isoprenoid biosynthesis that is thought to regulate the flux of isoprene intermediates through the sterol pathway; Belongs to the phytoene/squalene synthase family. | 0.975 |
| CYP51A1 | HSD17B7 | ENSPPYP00000019976 | ENSPPYP00000000676 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | HSD17B7 isoform 2. | 0.968 |
| CYP51A1 | LSS | ENSPPYP00000019976 | ENSPPYP00000012870 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family. | 0.985 |
| CYP51A1 | MSMO1 | ENSPPYP00000019976 | ENSPPYP00000016960 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | Methylsterol monooxygenase 1; Catalyzes the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol; Belongs to the sterol desaturase family. | 0.964 |
| CYP51A1 | SC5D | ENSPPYP00000019976 | ENSPPYP00000004558 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | Sterol-C5-desaturase; Belongs to the sterol desaturase family. | 0.945 |
| DHCR24 | CH25H | ENSPPYP00000001525 | ENSPPYP00000002851 | DHCR24 isoform 1. | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. | 0.908 |
| DHCR24 | CYP51A1 | ENSPPYP00000001525 | ENSPPYP00000019976 | DHCR24 isoform 1. | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | 0.986 |
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