TIRAP protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FADD	LY96	ENSPPYP00000003427	ENSPPYP00000020954	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Lymphocyte antigen 96.	0.554
FADD	MYD88	ENSPPYP00000003427	ENSPPYP00000015673	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.963
FADD	TIRAP	ENSPPYP00000003427	ENSPPYP00000004627	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	TIR domain containing adaptor protein.	0.923
FADD	TLR4	ENSPPYP00000003427	ENSPPYP00000021908	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	TLR4 isoform 1; Belongs to the Toll-like receptor family.	0.660
FADD	TRAF6	ENSPPYP00000003427	ENSPPYP00000003845	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.948
IRAK1	IRAK4	ENSPPYP00000023353	ENSPPYP00000005053	Interleukin 1 receptor associated kinase 1.	IRAK4 isoform 6.	0.999
IRAK1	LY96	ENSPPYP00000023353	ENSPPYP00000020954	Interleukin 1 receptor associated kinase 1.	Lymphocyte antigen 96.	0.693
IRAK1	MYD88	ENSPPYP00000023353	ENSPPYP00000015673	Interleukin 1 receptor associated kinase 1.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.999
IRAK1	TIRAP	ENSPPYP00000023353	ENSPPYP00000004627	Interleukin 1 receptor associated kinase 1.	TIR domain containing adaptor protein.	0.977
IRAK1	TLR2	ENSPPYP00000023353	ENSPPYP00000016910	Interleukin 1 receptor associated kinase 1.	Toll-like receptor.	0.694
IRAK1	TLR4	ENSPPYP00000023353	ENSPPYP00000021908	Interleukin 1 receptor associated kinase 1.	TLR4 isoform 1; Belongs to the Toll-like receptor family.	0.777
IRAK1	TLR6	ENSPPYP00000023353	ENSPPYP00000016388	Interleukin 1 receptor associated kinase 1.	Toll-like receptor.	0.418
IRAK1	TOLLIP	ENSPPYP00000023353	ENSPPYP00000003370	Interleukin 1 receptor associated kinase 1.	Toll interacting protein.	0.974
IRAK1	TRAF6	ENSPPYP00000023353	ENSPPYP00000003845	Interleukin 1 receptor associated kinase 1.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.999
IRAK4	IRAK1	ENSPPYP00000005053	ENSPPYP00000023353	IRAK4 isoform 6.	Interleukin 1 receptor associated kinase 1.	0.999
IRAK4	LY96	ENSPPYP00000005053	ENSPPYP00000020954	IRAK4 isoform 6.	Lymphocyte antigen 96.	0.483
IRAK4	MYD88	ENSPPYP00000005053	ENSPPYP00000015673	IRAK4 isoform 6.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.999
IRAK4	TIRAP	ENSPPYP00000005053	ENSPPYP00000004627	IRAK4 isoform 6.	TIR domain containing adaptor protein.	0.989
IRAK4	TLR2	ENSPPYP00000005053	ENSPPYP00000016910	IRAK4 isoform 6.	Toll-like receptor.	0.699
IRAK4	TLR4	ENSPPYP00000005053	ENSPPYP00000021908	IRAK4 isoform 6.	TLR4 isoform 1; Belongs to the Toll-like receptor family.	0.984