TIRAP protein (Pongo abelii) - STRING interaction network

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Predicted Interactions

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Score

TIRAP

TIR domain containing adaptor protein. (221 aa)

Predicted Functional Partners:

MYD88

0.996

TLR4

0.995

TRAF6

0.993

TLR2

0.992

IRAK1

0.990

TLR6

0.984

IRAK4

0.980

LY96

0.966

FADD

0.918

TLR3

0.880

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FADD	IRAK1	ENSPPYP00000003427	ENSPPYP00000023353	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Interleukin 1 receptor associated kinase 1.	0.446
FADD	LY96	ENSPPYP00000003427	ENSPPYP00000020954	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Lymphocyte antigen 96.	0.471
FADD	MYD88	ENSPPYP00000003427	ENSPPYP00000015673	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.974
FADD	TIRAP	ENSPPYP00000003427	ENSPPYP00000004627	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	TIR domain containing adaptor protein.	0.918
FADD	TLR3	ENSPPYP00000003427	ENSPPYP00000017042	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.581
FADD	TLR4	ENSPPYP00000003427	ENSPPYP00000021908	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	TLR4 isoform 1; Belongs to the Toll-like receptor family.	0.664
FADD	TRAF6	ENSPPYP00000003427	ENSPPYP00000003845	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.757
IRAK1	FADD	ENSPPYP00000023353	ENSPPYP00000003427	Interleukin 1 receptor associated kinase 1.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.446
IRAK1	IRAK4	ENSPPYP00000023353	ENSPPYP00000005053	Interleukin 1 receptor associated kinase 1.	IRAK4 isoform 6.	0.999
IRAK1	LY96	ENSPPYP00000023353	ENSPPYP00000020954	Interleukin 1 receptor associated kinase 1.	Lymphocyte antigen 96.	0.796
IRAK1	MYD88	ENSPPYP00000023353	ENSPPYP00000015673	Interleukin 1 receptor associated kinase 1.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.999
IRAK1	TIRAP	ENSPPYP00000023353	ENSPPYP00000004627	Interleukin 1 receptor associated kinase 1.	TIR domain containing adaptor protein.	0.990
IRAK1	TLR2	ENSPPYP00000023353	ENSPPYP00000016910	Interleukin 1 receptor associated kinase 1.	Toll-like receptor.	0.762
IRAK1	TLR3	ENSPPYP00000023353	ENSPPYP00000017042	Interleukin 1 receptor associated kinase 1.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.832
IRAK1	TLR4	ENSPPYP00000023353	ENSPPYP00000021908	Interleukin 1 receptor associated kinase 1.	TLR4 isoform 1; Belongs to the Toll-like receptor family.	0.823
IRAK1	TLR6	ENSPPYP00000023353	ENSPPYP00000016388	Interleukin 1 receptor associated kinase 1.	Toll-like receptor.	0.619
IRAK1	TRAF6	ENSPPYP00000023353	ENSPPYP00000003845	Interleukin 1 receptor associated kinase 1.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.999
IRAK4	IRAK1	ENSPPYP00000005053	ENSPPYP00000023353	IRAK4 isoform 6.	Interleukin 1 receptor associated kinase 1.	0.999
IRAK4	LY96	ENSPPYP00000005053	ENSPPYP00000020954	IRAK4 isoform 6.	Lymphocyte antigen 96.	0.541
IRAK4	MYD88	ENSPPYP00000005053	ENSPPYP00000015673	IRAK4 isoform 6.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.999