Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ADAMTS15ADAM metallopeptidase with thrombospondin type 1 motif 15. (950 aa)    
Predicted Functional Partners:
ADAMTS4
A disintegrin and metalloproteinase with thrombospondin motifs 4; Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Cleaves aggrecan at the '392-Glu-|- Ala-393' site.
    
 0.783
ADAMTS12
ADAMTS12 isoform 1.
     
 0.574
ADAMTS7
ADAMTS7 isoform 1.
 
   
0.514
CR201_G0049106
USF2 isoform 1.
    
 
 0.489
POFUT2
Protein O-fucosyltransferase 2.
     
 0.445
THSD7A
THSD7A isoform 1.
     
  0.436
ADAMTS13
ADAMTS13 isoform 5.
     
 0.436
RARRES2
Retinoic acid receptor responder protein 2; Adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through activation of the chemokine-like receptor 1 (CMKLR1). Its other ligands include G protein-coupled receptor 1 (GPR1) and chemokine receptor-like 2 (CCRL2). Positively regulates adipocyte differentiation, modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a process essential for the expansion of white adipose tissue. Also acts as a proinflammatory adipokine, causing an i [...]
      
 0.435
ADAMTS18
ADAM metallopeptidase with thrombospondin type 1 motif 18.
     
 0.433
ADAMTS16
ADAM metallopeptidase with thrombospondin type 1 motif 16.
     
 0.433
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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