node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DCP1A | DCP1B | ENSPPYP00000015428 | ENSPPYP00000004723 | DCP1A isoform 1. | mRNA-decapping enzyme 1B; May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7- methyl guanine cap structure from mRNA molecules, yielding a 5'- phosphorylated mRNA fragment and 7m-GDP (By similarity). | 0.998 |
DCP1A | DCP2 | ENSPPYP00000015428 | ENSPPYP00000018067 | DCP1A isoform 1. | m7GpppN-mRNA hydrolase; Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication- dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking an RNA moiety. The presence of a N(6)-methyladenosine methylation at the second transcr [...] | 0.947 |
DCP1A | DDX6 | ENSPPYP00000015428 | ENSPPYP00000004516 | DCP1A isoform 1. | Probable ATP-dependent RNA helicase DDX6; In the process of mRNA degradation, may play a role in mRNA decapping. | 0.997 |
DCP1A | EDC3 | ENSPPYP00000015428 | ENSPPYP00000007534 | DCP1A isoform 1. | Enhancer of mRNA-decapping protein 3; Binds single-stranded RNA. Involved in the process of mRNA degradation and in the positive regulation of mRNA decapping (By similarity); Belongs to the EDC3 family. | 0.997 |
DCP1A | EDC4 | ENSPPYP00000015428 | ENSPPYP00000008440 | DCP1A isoform 1. | Enhancer of mRNA decapping 4. | 0.998 |
DCP1A | ENSPPYP00000017543 | ENSPPYP00000015428 | ENSPPYP00000017543 | DCP1A isoform 1. | annotation not available | 0.999 |
DCP1A | KIFBP | ENSPPYP00000015428 | ENSPPYP00000002772 | DCP1A isoform 1. | KIF1 binding protein. | 0.818 |
DCP1A | NAXE | ENSPPYP00000015428 | ENSPPYP00000000824 | DCP1A isoform 1. | NAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. | 0.834 |
DCP1A | UPF1 | ENSPPYP00000015428 | ENSPPYP00000010923 | DCP1A isoform 1. | UPF1 isoform 2. | 0.956 |
DCP1A | XRN1 | ENSPPYP00000015428 | ENSPPYP00000015851 | DCP1A isoform 1. | 5'-3' exoribonuclease 1. | 0.993 |
DCP1B | DCP1A | ENSPPYP00000004723 | ENSPPYP00000015428 | mRNA-decapping enzyme 1B; May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7- methyl guanine cap structure from mRNA molecules, yielding a 5'- phosphorylated mRNA fragment and 7m-GDP (By similarity). | DCP1A isoform 1. | 0.998 |
DCP1B | DCP2 | ENSPPYP00000004723 | ENSPPYP00000018067 | mRNA-decapping enzyme 1B; May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7- methyl guanine cap structure from mRNA molecules, yielding a 5'- phosphorylated mRNA fragment and 7m-GDP (By similarity). | m7GpppN-mRNA hydrolase; Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication- dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking an RNA moiety. The presence of a N(6)-methyladenosine methylation at the second transcr [...] | 0.842 |
DCP1B | DDX6 | ENSPPYP00000004723 | ENSPPYP00000004516 | mRNA-decapping enzyme 1B; May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7- methyl guanine cap structure from mRNA molecules, yielding a 5'- phosphorylated mRNA fragment and 7m-GDP (By similarity). | Probable ATP-dependent RNA helicase DDX6; In the process of mRNA degradation, may play a role in mRNA decapping. | 0.992 |
DCP1B | EDC3 | ENSPPYP00000004723 | ENSPPYP00000007534 | mRNA-decapping enzyme 1B; May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7- methyl guanine cap structure from mRNA molecules, yielding a 5'- phosphorylated mRNA fragment and 7m-GDP (By similarity). | Enhancer of mRNA-decapping protein 3; Binds single-stranded RNA. Involved in the process of mRNA degradation and in the positive regulation of mRNA decapping (By similarity); Belongs to the EDC3 family. | 0.993 |
DCP1B | EDC4 | ENSPPYP00000004723 | ENSPPYP00000008440 | mRNA-decapping enzyme 1B; May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7- methyl guanine cap structure from mRNA molecules, yielding a 5'- phosphorylated mRNA fragment and 7m-GDP (By similarity). | Enhancer of mRNA decapping 4. | 0.983 |
DCP1B | ENSPPYP00000017543 | ENSPPYP00000004723 | ENSPPYP00000017543 | mRNA-decapping enzyme 1B; May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7- methyl guanine cap structure from mRNA molecules, yielding a 5'- phosphorylated mRNA fragment and 7m-GDP (By similarity). | annotation not available | 0.993 |
DCP1B | KIFBP | ENSPPYP00000004723 | ENSPPYP00000002772 | mRNA-decapping enzyme 1B; May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7- methyl guanine cap structure from mRNA molecules, yielding a 5'- phosphorylated mRNA fragment and 7m-GDP (By similarity). | KIF1 binding protein. | 0.818 |
DCP1B | NAXE | ENSPPYP00000004723 | ENSPPYP00000000824 | mRNA-decapping enzyme 1B; May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7- methyl guanine cap structure from mRNA molecules, yielding a 5'- phosphorylated mRNA fragment and 7m-GDP (By similarity). | NAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. | 0.834 |
DCP1B | UPF1 | ENSPPYP00000004723 | ENSPPYP00000010923 | mRNA-decapping enzyme 1B; May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7- methyl guanine cap structure from mRNA molecules, yielding a 5'- phosphorylated mRNA fragment and 7m-GDP (By similarity). | UPF1 isoform 2. | 0.811 |
DCP1B | XRN1 | ENSPPYP00000004723 | ENSPPYP00000015851 | mRNA-decapping enzyme 1B; May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7- methyl guanine cap structure from mRNA molecules, yielding a 5'- phosphorylated mRNA fragment and 7m-GDP (By similarity). | 5'-3' exoribonuclease 1. | 0.953 |