| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DKFZp468G2216 | ENSPPYP00000017062 | ENSPPYP00000022865 | ENSPPYP00000017062 | AR isoform 8. | annotation not available | 0.866 |
| DKFZp468G2216 | FKBP4 | ENSPPYP00000022865 | ENSPPYP00000004732 | AR isoform 8. | Peptidylprolyl isomerase. | 0.982 |
| DKFZp468G2216 | FKBP5 | ENSPPYP00000022865 | ENSPPYP00000018489 | AR isoform 8. | Peptidyl-prolyl cis-trans isomerase FKBP5; Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded (By similarity). | 0.971 |
| DKFZp468G2216 | HSP90AA1 | ENSPPYP00000022865 | ENSPPYP00000006994 | AR isoform 8. | HSP90AA1 isoform 6. | 0.866 |
| DKFZp468G2216 | HSP90AB1 | ENSPPYP00000022865 | ENSPPYP00000018631 | AR isoform 8. | Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] | 0.982 |
| DKFZp468G2216 | NR3C1 | ENSPPYP00000022865 | ENSPPYP00000017784 | AR isoform 8. | Glucocorticoid receptor; Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP [...] | 0.769 |
| DKFZp468G2216 | NR3C2 | ENSPPYP00000022865 | ENSPPYP00000016883 | AR isoform 8. | NR3C2 isoform 1. | 0.689 |
| DKFZp468G2216 | PGR | ENSPPYP00000022865 | ENSPPYP00000004346 | AR isoform 8. | PGR isoform 1. | 0.861 |
| DKFZp468G2216 | PTGES3 | ENSPPYP00000022865 | ENSPPYP00000005319 | AR isoform 8. | Prostaglandin E synthase 3; Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway. | 0.964 |
| ENSPPYP00000017062 | DKFZp468G2216 | ENSPPYP00000017062 | ENSPPYP00000022865 | annotation not available | AR isoform 8. | 0.866 |
| ENSPPYP00000017062 | FKBP4 | ENSPPYP00000017062 | ENSPPYP00000004732 | annotation not available | Peptidylprolyl isomerase. | 0.926 |
| ENSPPYP00000017062 | FKBP5 | ENSPPYP00000017062 | ENSPPYP00000018489 | annotation not available | Peptidyl-prolyl cis-trans isomerase FKBP5; Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded (By similarity). | 0.905 |
| ENSPPYP00000017062 | HSP90AB1 | ENSPPYP00000017062 | ENSPPYP00000018631 | annotation not available | Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] | 0.983 |
| ENSPPYP00000017062 | NR3C1 | ENSPPYP00000017062 | ENSPPYP00000017784 | annotation not available | Glucocorticoid receptor; Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP [...] | 0.892 |
| ENSPPYP00000017062 | NR3C2 | ENSPPYP00000017062 | ENSPPYP00000016883 | annotation not available | NR3C2 isoform 1. | 0.406 |
| ENSPPYP00000017062 | PGR | ENSPPYP00000017062 | ENSPPYP00000004346 | annotation not available | PGR isoform 1. | 0.723 |
| ENSPPYP00000017062 | PTGES3 | ENSPPYP00000017062 | ENSPPYP00000005319 | annotation not available | Prostaglandin E synthase 3; Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway. | 0.942 |
| ENSPPYP00000017062 | STIP1 | ENSPPYP00000017062 | ENSPPYP00000003602 | annotation not available | STIP1 isoform 2. | 0.951 |
| FKBP4 | DKFZp468G2216 | ENSPPYP00000004732 | ENSPPYP00000022865 | Peptidylprolyl isomerase. | AR isoform 8. | 0.982 |
| FKBP4 | ENSPPYP00000017062 | ENSPPYP00000004732 | ENSPPYP00000017062 | Peptidylprolyl isomerase. | annotation not available | 0.926 |
