| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APLP2 | CLSTN3 | ENSPPYP00000004646 | ENSPPYP00000004814 | Amyloid beta precursor like protein 2. | Calsyntenin-3; May modulate calcium-mediated postsynaptic signals. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. | 0.497 |
| CBLN1 | CLSTN3 | ENSPPYP00000008280 | ENSPPYP00000004814 | Cerebellin 1 precursor. | Calsyntenin-3; May modulate calcium-mediated postsynaptic signals. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. | 0.510 |
| CDCA3 | CLSTN3 | ENSPPYP00000004791 | ENSPPYP00000004814 | CDCA3 isoform 4. | Calsyntenin-3; May modulate calcium-mediated postsynaptic signals. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. | 0.517 |
| CDCA3 | USP5 | ENSPPYP00000004791 | ENSPPYP00000004792 | CDCA3 isoform 4. | Ubiquitin carboxyl-terminal hydrolase 5; Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys- 48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity (By similarity). | 0.899 |
| CLSTN3 | APLP2 | ENSPPYP00000004814 | ENSPPYP00000004646 | Calsyntenin-3; May modulate calcium-mediated postsynaptic signals. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. | Amyloid beta precursor like protein 2. | 0.497 |
| CLSTN3 | CBLN1 | ENSPPYP00000004814 | ENSPPYP00000008280 | Calsyntenin-3; May modulate calcium-mediated postsynaptic signals. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. | Cerebellin 1 precursor. | 0.510 |
| CLSTN3 | CDCA3 | ENSPPYP00000004814 | ENSPPYP00000004791 | Calsyntenin-3; May modulate calcium-mediated postsynaptic signals. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. | CDCA3 isoform 4. | 0.517 |
| CLSTN3 | ERP27 | ENSPPYP00000004814 | ENSPPYP00000004943 | Calsyntenin-3; May modulate calcium-mediated postsynaptic signals. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. | Endoplasmic reticulum protein 27. | 0.647 |
| CLSTN3 | HACD4 | ENSPPYP00000004814 | ENSPPYP00000021494 | Calsyntenin-3; May modulate calcium-mediated postsynaptic signals. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] | 0.569 |
| CLSTN3 | MDGA1 | ENSPPYP00000004814 | ENSPPYP00000018528 | Calsyntenin-3; May modulate calcium-mediated postsynaptic signals. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. | MDGA1 isoform 1. | 0.509 |
| CLSTN3 | MYBPC2 | ENSPPYP00000004814 | ENSPPYP00000011513 | Calsyntenin-3; May modulate calcium-mediated postsynaptic signals. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. | MYBPC2 isoform 1. | 0.617 |
| CLSTN3 | SH3BP5L | ENSPPYP00000004814 | ENSPPYP00000000006 | Calsyntenin-3; May modulate calcium-mediated postsynaptic signals. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. | SH3 domain-binding protein 5-like; Functions as guanine nucleotide exchange factor (GEF) for RAB11A. | 0.726 |
| CLSTN3 | TELO2 | ENSPPYP00000004814 | ENSPPYP00000007874 | Calsyntenin-3; May modulate calcium-mediated postsynaptic signals. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. | TELO2 isoform 2. | 0.509 |
| CLSTN3 | USP5 | ENSPPYP00000004814 | ENSPPYP00000004792 | Calsyntenin-3; May modulate calcium-mediated postsynaptic signals. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. | Ubiquitin carboxyl-terminal hydrolase 5; Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys- 48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity (By similarity). | 0.528 |
| ERP27 | CLSTN3 | ENSPPYP00000004943 | ENSPPYP00000004814 | Endoplasmic reticulum protein 27. | Calsyntenin-3; May modulate calcium-mediated postsynaptic signals. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. | 0.647 |
| ERP27 | MYBPC2 | ENSPPYP00000004943 | ENSPPYP00000011513 | Endoplasmic reticulum protein 27. | MYBPC2 isoform 1. | 0.596 |
| HACD4 | CLSTN3 | ENSPPYP00000021494 | ENSPPYP00000004814 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] | Calsyntenin-3; May modulate calcium-mediated postsynaptic signals. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. | 0.569 |
| HACD4 | MDGA1 | ENSPPYP00000021494 | ENSPPYP00000018528 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] | MDGA1 isoform 1. | 0.479 |
| MDGA1 | CLSTN3 | ENSPPYP00000018528 | ENSPPYP00000004814 | MDGA1 isoform 1. | Calsyntenin-3; May modulate calcium-mediated postsynaptic signals. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. | 0.509 |
| MDGA1 | HACD4 | ENSPPYP00000018528 | ENSPPYP00000021494 | MDGA1 isoform 1. | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] | 0.479 |
