| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACOX1 | PEX10 | ENSPPYP00000009707 | ENSPPYP00000002293 | Peroxisomal acyl-CoA oxidase 1, A chain; Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs (By similarity). Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length (By similarity). Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs (By similarity). | PEX10 isoform 2. | 0.689 |
| ACOX1 | PEX12 | ENSPPYP00000009707 | ENSPPYP00000009205 | Peroxisomal acyl-CoA oxidase 1, A chain; Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs (By similarity). Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length (By similarity). Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs (By similarity). | Peroxisome assembly protein 12; Required for protein import into peroxisomes. Belongs to the pex2/pex10/pex12 family. | 0.613 |
| ACOX1 | PEX13 | ENSPPYP00000009707 | ENSPPYP00000013816 | Peroxisomal acyl-CoA oxidase 1, A chain; Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs (By similarity). Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length (By similarity). Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs (By similarity). | Peroxisomal biogenesis factor 13. | 0.681 |
| ACOX1 | PEX14 | ENSPPYP00000009707 | ENSPPYP00000002199 | Peroxisomal acyl-CoA oxidase 1, A chain; Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs (By similarity). Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length (By similarity). Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs (By similarity). | PEX14 isoform 2. | 0.748 |
| ACOX1 | PEX2 | ENSPPYP00000009707 | ENSPPYP00000020963 | Peroxisomal acyl-CoA oxidase 1, A chain; Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs (By similarity). Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length (By similarity). Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs (By similarity). | PEX2 isoform 1. | 0.610 |
| ACOX1 | PEX5 | ENSPPYP00000009707 | ENSPPYP00000004816 | Peroxisomal acyl-CoA oxidase 1, A chain; Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs (By similarity). Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length (By similarity). Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs (By similarity). | Peroxisomal biogenesis factor 5. | 0.939 |
| ACOX1 | PEX5L | ENSPPYP00000009707 | ENSPPYP00000016019 | Peroxisomal acyl-CoA oxidase 1, A chain; Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs (By similarity). Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length (By similarity). Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs (By similarity). | PEX5L isoform 2. | 0.720 |
| ACOX1 | PEX7 | ENSPPYP00000009707 | ENSPPYP00000019078 | Peroxisomal acyl-CoA oxidase 1, A chain; Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs (By similarity). Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length (By similarity). Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs (By similarity). | Peroxisomal biogenesis factor 7. | 0.449 |
| ATM | PEX5 | ENSPPYP00000004403 | ENSPPYP00000004816 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Peroxisomal biogenesis factor 5. | 0.965 |
| ATM | PEX5L | ENSPPYP00000004403 | ENSPPYP00000016019 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | PEX5L isoform 2. | 0.802 |
| PEX10 | ACOX1 | ENSPPYP00000002293 | ENSPPYP00000009707 | PEX10 isoform 2. | Peroxisomal acyl-CoA oxidase 1, A chain; Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs (By similarity). Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length (By similarity). Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs (By similarity). | 0.689 |
| PEX10 | PEX12 | ENSPPYP00000002293 | ENSPPYP00000009205 | PEX10 isoform 2. | Peroxisome assembly protein 12; Required for protein import into peroxisomes. Belongs to the pex2/pex10/pex12 family. | 0.996 |
| PEX10 | PEX13 | ENSPPYP00000002293 | ENSPPYP00000013816 | PEX10 isoform 2. | Peroxisomal biogenesis factor 13. | 0.979 |
| PEX10 | PEX14 | ENSPPYP00000002293 | ENSPPYP00000002199 | PEX10 isoform 2. | PEX14 isoform 2. | 0.976 |
| PEX10 | PEX2 | ENSPPYP00000002293 | ENSPPYP00000020963 | PEX10 isoform 2. | PEX2 isoform 1. | 0.996 |
| PEX10 | PEX5 | ENSPPYP00000002293 | ENSPPYP00000004816 | PEX10 isoform 2. | Peroxisomal biogenesis factor 5. | 0.974 |
| PEX10 | PEX5L | ENSPPYP00000002293 | ENSPPYP00000016019 | PEX10 isoform 2. | PEX5L isoform 2. | 0.896 |
| PEX10 | PEX6 | ENSPPYP00000002293 | ENSPPYP00000018593 | PEX10 isoform 2. | Peroxisomal biogenesis factor 6. | 0.879 |
| PEX10 | PEX7 | ENSPPYP00000002293 | ENSPPYP00000019078 | PEX10 isoform 2. | Peroxisomal biogenesis factor 7. | 0.887 |
| PEX12 | ACOX1 | ENSPPYP00000009205 | ENSPPYP00000009707 | Peroxisome assembly protein 12; Required for protein import into peroxisomes. Belongs to the pex2/pex10/pex12 family. | Peroxisomal acyl-CoA oxidase 1, A chain; Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs (By similarity). Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length (By similarity). Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs (By similarity). | 0.613 |
